Results 41 to 50 of about 5,122,356 (332)

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

open access: yesPLoS ONE, 2015
Although periodontitis has been implicated as a risk factor for various systemic diseases, the precise mechanisms by which periodontitis induces systemic disease remain to be elucidated.
Mayuka Nakajima   +7 more
semanticscholar   +1 more source

Effects of BCL oral administation and herbal acupuncture at BL18, BL19 on Liver function changes induced by Alcohol in the mice

open access: yesJournal of Pharmacopuncture, 2002
This dissertation was designed to evaluate the effect of BCL(refinded Bambusae Caulis in Liqua-men) oral administration and herbal acupuncture on alcohol metabolism and liver function. For this study.
Sa-Hyun Park
doaj   +1 more source

Converting cyclosporine A from intravenous to oral administration in hematopoietic stem cell transplant recipients and the role of azole antifungals [PDF]

open access: yes, 2018
Purpose: Cyclosporine A (CsA) is the most widely used immunosuppressive agent after a hematopoietic stem cell transplantation (HSCT). Although recommendations for CsA dose conversion from intravenous to oral administration differ from 1:1 to 1:3, most ...
Andrews, L.M. (Louise)   +8 more
core   +1 more source

Microemulsions for oral administration and their therapeutic applications [PDF]

open access: yesExpert Opinion on Drug Delivery, 2012
The microemulsion concept was introduced in 1943 by Hoar and Schulman. Self-microemulsifying drug delivery systems (S(M)EDDS) are much more recent and can be described as isotropic solutions of oils and surfactants that form oil-in-water O/W microemulsions when they are poured into an aqueous medium.
Gibaud, Stéphane, Attivi, David
openaire   +5 more sources

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors

open access: yesFrontiers in Pharmacology, 2020
The oral route is by far the most common route of drug administration in the gastrointestinal tract and can be used for both systemic drug delivery and for treating local gastrointestinal diseases.
S. Hua
semanticscholar   +1 more source

Methotrexate efficacy and tolerability after switching from oral to subcutaneous route of administration in juvenile idiopathic arthritis

open access: yesRheumatology, 2016
Objectives : Methotrexate (MTX) is one of the most frequently used, highly effective disease-modifying drugs in juvenile idiopathic arthritis (JIA) therapy.
Zbigniew Żuber   +6 more
doaj   +1 more source

Broncho-Vaxom attenuates allergic airway inflammation by restoring GSK3β-related T regulatory cell insufficiency. [PDF]

open access: yesPLoS ONE, 2014
Oral administration of bacterial extracts (eg, Broncho-Vaxom (BV)) has been proposed to attenuate asthma through modulating Treg cells. However, the underlying mechanism has not been fully characterized.
Ran Fu   +8 more
doaj   +1 more source

Transport of therapeutics across intestinal epithelium [PDF]

open access: yes, 2016
This chapter focuses on the oral administration of therapeutics. Patients prefer oral administration because it is painless and simple to implement.
E. Roger, F. Lagarce, S. Muro
core   +3 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

open access: yesPharmaceutics, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj   +1 more source

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