Results 61 to 70 of about 4,385,684 (306)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

IMMUNOLOGIC PREVENTION OF IDDM BY ORAL ADMINISTRATION OF GLUTAMIC ACID DECARBOXYLASE [PDF]

Acta Medica Iranica, 1999
We have Investigated the preventive effects of oral administration of isolated E.coli ghttam'tc acid decarboxylase (GAD) in animal models. Based on our results, the blood glucose levels were reduced by oral administration of GAD to rats 14 days before ...
L. Yazdchi Mari, Sh. Rajieii. R. Yazdanparast   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pharmacokinetics and thermal anti-nociceptive effects of oral morphine in horses

Frontiers in Veterinary Science
IntroductionMorphine is an effective analgesic in horses, however, IV administration at therapeutic doses has been shown to produce dose-dependent neuroexcitation and unwanted gastrointestinal effects.
Heather K. Knych, Heather K. Knych, Stacy J. Steinmetz, Megan L. Traynham, Daniel S. McKemie, Philip H. Kass   +5 more
doaj   +1 more source

Oral esketamine for treatment-resistant depression: rationale and design of a randomized controlled trial

BMC Psychiatry, 2019
Background There is an urgent need to develop additional treatment strategies for patients with treatment-resistant depression (TRD). The rapid but short-lived antidepressant effects of intravenous (IV) ketamine as a racemic mixture have been shown ...
Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Jeanine Kamphuis, Antoinette D. I. van Asselt, Daan J. Touw, Marije aan het Rot, Robert A. Schoevers   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The difficulties experienced during the preparation and administration of oral drugs by parents at home: a cross-sectional study from Palestine

BMC Pediatrics, 2020
Background Failure to properly administer drugs to children at home may cause adverse events, which makes it a challenging job for parents or caregivers.
Ra’fat Ali, Abdullah Shadeed, Hasan Fitian, Sa’ed H. Zyoud   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect against Ischemia–Reperfusion Injury

Nutrition and Metabolic Insights, 2016
Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans.
Janelle L. Davis, Hunter L. Paris, Joseph W. Beals, Scott E. Binns, Gregory R. Giordano, Rebecca L. Scalzo, Melani M. Schweder, Emek Blair, Christopher Bell   +8 more
doaj   +1 more source

Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Particle and Fibre Toxicology, 2014
ObjectiveThe aim of this study was to obtain kinetic data that can be used in human risk assessment of titanium dioxide nanomaterials.MethodsTissue distribution and blood kinetics of various titanium dioxide nanoparticles (NM-100, NM-101, NM-102, NM-103,
L. Geraets, A. Oomen, P. Krystek, N. Jacobsen, H. Wallin, M. Laurentie, H. W. Verharen, E. Brandon, W. D. De Jong   +8 more
semanticscholar   +1 more source