Results 51 to 60 of about 2,148,141 (263)

Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration

, 2016
Tacrolimus (TCR) is an immunosuppressive drug used by oral administration. Intravenous (IV) TCR administration is required under conditions of gastrointestinal diseases or abdominal surgery at the onset of paralytic ileus.
Apicella, Luca, Luca Apicella, Mosca, Teresa, FEDERICO, STEFANO, SANTANGELO, MICHELE, BALLETTA, MARIO MARIA, Michele Santangelo, Mario Maria Balletta, Teresa Mosca, TARANTINO, GIOVANNI, Rosa Carrano, Luigi Russo, Carrano, Rosa, Massimo Sabbatini, RUSSO, LUIGI, Stefano Federico, Nappi, Riccardo, CAPONE, DOMENICO, Giovanni Tarantino, SABBATINI, MASSIMO, Domenico Capone, Riccardo Nappi   +21 more
core   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Outcomes of early first‐trimester medical abortion following bariatric surgery: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare medical termination of pregnancy (TOP) failure in patients with and without prior bariatric surgery (BS) and to compare outcomes by BS subtype. Methods We performed a retrospective cohort study of medical TOP at a single university teaching center between January 2019 and April 2024.
Shai Ingram, Adi Dayan‐Schwartz, Uri Kaplan, Gali Garmi, Noah Zafran   +4 more
wiley   +1 more source

Recombinant activated factor VIIa for severe postpartum hemorrhage in Africa: Evidence, appropriate use, and research priorities—A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Postpartum hemorrhage (PPH) accounts for 30%–50% of maternal mortality in Africa and occurs in the context of pre‐existing anemia, limited blood product availability, delayed recognition, and constrained referral systems. Although bundle‐based care (E‐MOTIVE), early tranexamic acid (TXA), and uterotonics have substantially improved outcomes, a
Johnny Mahlangu, Haroun Rhemtula, Jarrod Zamparini, Lawrence Chauke   +3 more
wiley   +1 more source

SUBLINGUAL CAPTOPRIL - A PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION

, 1991
In this study we compared the pharmacokinetics and pharmacodynamics of captopril after sublingual and peroral administration. Single 25 mg doses of captopril were administered sublingually and perorally on two different occasions in a randomised cross ...
McElnay, James, Rusk, R., Scott, M.G., Nicholls, D.P., Elborn, J.S., Alfuraih, T.A., Mcmahon, J.   +6 more
core   +3 more sources

Application limits of sublingual drug administration. 2 [PDF]

, 2011
Thesis briefly summarizes knowledge on the sublingual route of drug administration and brings newer facts about the pharmaceutical sublingual preparations, as well as basic information on dextran and its pharmaceutical use.
Krupauerová, Lucie
core   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Single-dose fentanyl sublingual spray for breakthrough cancer pain

Clinical Pharmacology: Advances and Applications, 2013
Donald R Taylor Comprehensive Pain Care PC, Marietta, GA, USA Abstract: Breakthrough cancer pain (BTCP) is defined as a transient exacerbation of pain that arises in patients with otherwise controlled persistent pain. BTCP typically has a rapid onset and
Taylor DR
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