Results 61 to 70 of about 1,812,803 (254)

Current status of sublingual immunotherapy in the United States

World Allergy Organization Journal, 2014
Sublingual immunotherapy (SLIT) use in the United States to date has been limited, despite common use and demonstrated efficacy elsewhere in the world.
Shelby Elenburg, Michael S. Blaiss
doaj   +1 more source

Clinical applications of wearable devices for individuals with at‐risk substance use and substance use disorders: A systematic review

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Managing substance use disorders (SUDs) is limited by the lack of longitudinal clinical data during active use and recovery. Wearable devices may help address this gap by capturing physiological and behavioral data in real‐world settings.
Alexandra Sas, Matthew E. Sloan, Yaoyi Xing, Ethan Kim, Dhvani Mehta, Anna Mouzenian, Lena C. Quilty, Jeffrey D. Wardell, Shannon Lange, Daniel Felsky, Victor M. Tang   +10 more
wiley   +1 more source

Sublingual Drug Delivery

, 2008
The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation.
Li, Xiaoling, Goswami, Tarun, Jasti, Bhaskara   +2 more
core   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers

, 2014
Aims: The immunosuppressant tacrolimus is usually administered orally. When this is not feasible, other routes of administration may be useful. Previous research suggested that tacrolimus may be applied sublingually or rectally.
Stifft, Frank, Christiaans, Maarten, Vanmolkot, F., Scheffers, I., Vanmolkot, Floris, Stifft, F., Neef, C., Scheffers, Ingrid, Ingrid Scheffers, Van Bortel, Lucas, Cees Neef, Floris Vanmolkot, Neef, Cees, van Bortel, L., Maarten Christiaans, Christiaans, M., Frank Stifft, Luc van Bortel   +17 more
core   +1 more source

Transition between subcutaneous and sublingual allergen immunotherapy: Recommendations of the Brazilian Association of Allergy and Immunology (ASBAI)

Journal of Allergy and Clinical Immunology: Global
The use of allergen immunotherapy (AIT) in Brazil has specific regional conditions owing to the pattern of allergen sensitization, as well as to genetic, socioeconomic, and cultural characteristics.
Fernando Monteiro Aarestrup, MD, PhD, Ernesto Akio Taketomi, MD, PhD, Clóvis Eduardo Santos Galvão, MD, PhD, Gil Bardini Alves, MD, MSc, Geórgia Véras de Araújo Gueiros Lira, MD, PhD, Marcos Reis Gonçalves, MD, MSc, Mariana Graça Couto Miziara, MD, Sidney Souteban Maranhão Casado, MD, Veridiana Aun Rufino Pereira, MD, PhD, Dirceu Solé, MD, PhD, Ekaterini Simoes Goudouris, MD, PhD, Fabio Chigres Kuschnir, MD, PhD   +11 more
doaj   +1 more source

Preventive Application of House Dust Mite‐Sublingual Immunotherapy Induces Blocking Antibodies in Sensitized Preschool Children

Allergy, EarlyView.
HDM‐pSLIT induced IgG, IgG1, and IgG4 specific to major HDM allergens in sensitized non‐allergic preschool children without increasing HDM‐sIgE. It blunted the development of new sensitizations and reduced HDM reactivity in skin and basophils. HDM‐pSLIT treated children displayed a blocking effect on HDM‐induced basophil activation.
Varsha Dwivedi, Klara Schmidthaler, Hilal Demir, Justyna Sieber, René Gaupmann, Livia Mia Gona‐Höpler, Christina Bannert, Saskia Gruber, Eleonora Dehlink, Thomas Eiwegger, Alexandra Graf, Barbara Bohle, Zsolt Szépfalusi   +12 more
wiley   +1 more source

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations

Allergy, EarlyView.
Little is known about the factors driving AIT prescription in clinical practice, including the level of personalization from patient to patient. Patient‐centred factors theoretically would favour SLIT prescription. Doctors’ knowledge, training, and country influence the final decision on the route.
Carmen Vidal, Davide P. Caimmi, Pablo Rodriguez del Rio, Óscar Lado‐Baleato, Francisco Gude, Pilar Rico‐Nieto, Thomas B. Casale, Jorge A. Aguilar, Maryam Ali Al‐Nesf, Fatima Ashkanani, Adeeb Bulkhi, Juan C. Cardet, Claudia Almendarez, Silvia Caimmi, Iván Cherrez, Enza D’Auria, Stephanie Dramburg, Motohiro Ebisawa, Naoko Fusayasu, Maximiliano Gomez, Sandra Gonzalez‐Diaz, Carla Irani, Andrey Kamaev, Connie Katelaris, Narinder Kaur, Oksana KurBacheva, José I. Larco, Désirée Larenas‐Linnemann, Margaret Li, Olga Patricia Monge‐Ortega, Pablo Moreno, Oliver Pfaar, Cesar F. Pozo‐Beltrán, Marta E. Rubio, Jorge Sanchez, Giovanni Sedo, Silvia Uriarte, Lin Yang, Hao Chen, Rongfei Zhu, Pascal Demoly, Moises A. Calderon, on behalf of the CHOICE‐Global Survey Team   +42 more
wiley   +1 more source

Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double‐Blind Randomised Placebo‐Controlled Trial

Allergy, EarlyView.
This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić, Stephan C. Flory, Claudia C. V. Lang, Emma C. Widmer, Alexandra Chabot, Johannes M. Schmid, Tobias Andermatt, David Melillo, Bjarke Hviid‐Vyff, Maibritt Mardahl, Peter Schmid‐Grendelmeier, Thomas M. Kündig, Hans Jürgen Hoffmann, Pål Johansen   +13 more
wiley   +1 more source

Investigating the Analgesic Effect of Sublingual Glycerol Trinitrate (GTN) Spray as an Alternative Treatment in Renal Colic Pain: A Triple-Blinded Randomized Controlled Trial

Acta Medica Iranica
Renal colic, a severe pain caused by renal and urethral calculi, causes millions of patients to visit the emergency department (ED) worldwide each year.
Paria Sadat Ramezany, Mohammed Ali Shadram, Ahmad Reza Dehpour, Razieh Mohammad Jafari, Morteza Saeedi, Mehrad Aghili, Javad Seyedhosseini   +6 more
doaj   +1 more source