Results 81 to 90 of about 1,812,803 (254)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers
, 1989 The single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets were studied in a cross-over study in 6 healthy volunteers (median age 28 yr). The formulations had similar systemic availability.
M. Broggini +5 more
core +1 more source
Perioperative sublingual levodopa in Parkisnon's Disease: A useful alternative!
Indian Journal of Anaesthesia, 2017 Timely administration of dopamine agonists is of the essence in Parkinson's disease. The perioperative period especially for abdominal surgeries under general anaesthesia poses a challenge to oral drug administration.
Pritee H Bhirud, Jalpa Arvind Kate
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses
, 2011 Objective—To characterize pharmacokinetics and pharmacodynamics of detomidine gel administered sublingually in accordance with label instructions to establish appropriate withdrawal guidelines for horses before competition.
Scott D. Stanley +1 more
core +1 more source
Frontiers in Cellular and Infection MicrobiologyIntramuscular vaccines present limitations in eliciting robust mucosal immunity and preventing respiratory pathogens transmission. Sublingual vaccine administration offers promising advantages, including interconnected mucosal protection.
Erwan Sallard +3 more
doaj +1 more source
Sublingual immunotherapy: administration, dosages, use.
International journal of immunopathology and pharmacology, 2009 Allergen extracts for sublingual immunotherapy (SLIT) are currently marketed by several manufacturers, with administration schedules and amount of allergen(s) quite variable in the different products, although almost all are standardized biologically or immunologically.
Frati, F +7 more
openaire +2 more sources
Clinical &Experimental Allergy, EarlyView.A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson +14 more
wiley +1 more source
PLoS ONE, 2014 Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA) metastatic ...
Shailbala Singh +4 more
doaj +1 more source
Serum Estradiol Concentrations With Estradiol 0.06% Gel in Transgender and Gender‐Diverse Adults
Clinical Endocrinology, EarlyView.ABSTRACT Objective Transgender and gender‐diverse individuals undergoing estradiol therapy for gender affirmation are typically treated with oral or transdermal estradiol, with transdermal estradiol recommended for those aged > 45 years. There are limited data evaluating estradiol gel in gender‐affirming hormone therapy regimens. We aimed to assess the
Raquel A. Maggacis +2 more
wiley +1 more source