Results 101 to 110 of about 2,148,141 (263)

Introduction to pharmacology, and routes of drugs administration and absorption [PDF]

, 2017
This eChapter has an introduction to pharmacology and drug nomenclature followed by a detailed discussion of routes of administration starting with oral administration (with absorption from the gastrointestinal tract, and first pass liver metabolism ...
Doggrell, Sheila
core  

Pharmacokinetics of Buccally Administered Cannabidiol and Oral Carprofen During Single‐ and Repeated‐Dose Administration in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cannabidiol (CBD) is increasingly used as an adjunct treatment for chronic pain in dogs, but information on repeated‐dose pharmacokinetics and potential interactions with commonly used analgesics remains limited. This study evaluated the pharmacokinetics of buccally administered CBD, its major metabolites, and orally administered carprofen in ...
Tilen Vake, Katerina Tomsič, Žiga Žgank, Mihaela Klasić, Janja Babič, Zlatka Bajc, Jožica Dolenc, Gabrijela Tavčar Kalcher, Odon Planinšek, Tomaž Snoj   +9 more
wiley   +1 more source

A Phase I Pharmacokinetic and Bioavailability Study of a Sublingual Fentanyl Wafer in Healthy Volunteers

, 2012
Background: The sublingual administration of opioids is a simple and noninvasive method that provides rapid analgesia. In this phase I study we investigated the pharmacokinetics and bioavailability of a fentanyl wafer in healthy volunteers. The principal
Bruce Sunderland (677942), Stephen Lim (149062), Stephan Schug (16942933), Michael Paech (23361046), Yandi Liu (8981615)   +4 more
core   +2 more sources

Oral Lesions and Dental Status in Individuals Using Oral Tobacco‐Free Nicotine Pouches

Oral Diseases, EarlyView.
ABSTRACT Objectives Users of Swedish nicotine pouches and traditional oral tobacco‐derived pouches were compared to non‐users for clinical tissue responses and oral health status. In addition, the habits associated with snus use were also evaluated. Material and Methods In this cross‐sectional study, participants aged 18–30 were recruited from nine ...
Masoumeh Daneshian, Lars Fredriksson, Pia Skott, Karin Garming Legert   +3 more
wiley   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

, 1990
The deposition and clearance of a model substance, Tc E-HIDA, in the oral cavity/upper oesophagus and in the stomach after administration of lozenges, chewing gum and sublingual tablets has been followed by gamma scintigraphy in a group of healthy male ...
Frier, M., Rasmussen, S.N., Wilding, I.R., Melia, C.D., Davis, S.S., Andersen, C., Christrup, Lona Louring, Washington, N.   +7 more
core   +1 more source

SUBLINGUAL BUPRENORPHINE VS MIDAZOLAM FOR PREMEDICATION IN CHILDREN

Journal of Research in Medical Sciences, 2000
Background. Preanesthetic medication may reduce the risks of adverse psychological and physiological sequel of induction in children. Administration of premedication by sublingual route may provide the best compromise because of relatively rapid ...
V.A HASANI, A AMANNI, S JALALI MOTLAGH
doaj  

Unusual Giant Sialocyst Arising From Wharton's Duct: A Case Report

Oral Surgery, EarlyView.
ABSTRACT Background Head and neck masses in adults are a common reason for referral to maxillofacial surgeons and otolaryngologists, and most are benign. True salivary duct cysts (sialocysts) are extremely rare, accounting for < 1% of salivary duct lesions, and primarily involve minor salivary glands. Involvement of major salivary glands is exceptional,
Maksym Skrypnyk, Margarita Skikevych, Roman Skrypnyk, Volodymyr Mykytenko, Igor Skrypnyk, Liudmyla Voloshyna, Tetiana Yatsenko, Chun Xu, Satoshi Takahashi, Taro Osada, Koichi Hattori, Beate Heissig   +11 more
wiley   +1 more source

The role of antibiotics in preventing surgical complications in periodontology and implant dentistry

Periodontology 2000, EarlyView.
Abstract Antibiotics are commonly prescribed in periodontal and implant surgeries, either before, during or after surgery, to prevent postoperative infection and reduce early implant failure. However, the potential benefits may be undermined by the risks of resistance and sensitization, thus requiring a strict indication for prescription.
Zhaozhao Chen, Lan‐Lin Chiou, Javier Calatrava, Hom‐Lay Wang   +3 more
wiley   +1 more source