Results 101 to 110 of about 34,804 (275)

Five‐Grass‐Pollen Sublingual Immunotherapy Drops Are Efficacious and Well Tolerated in Adults: The RHAPSODY Phase III Trial

Allergy, EarlyView.
The RHAPSODY multinational study investigated 26 months of continuous treatment with 5‐grass‐pollen sublingual SLIT drops in adults with moderate‐to‐severe grass‐pollen‐induced allergic rhinoconjunctivitis. The primary efficacy endpoint (the average daily total combined score) showed statistically significant differences in favour of the active ...
Alain Didier, Ruta Gronskyte Juhl, Terrie Dalgaard, Antoine Chartier, Philippe Devillier   +4 more
wiley   +1 more source

Cutting-edge research frontiers in oral cavity vaccines for respiratory diseases: a roadmap for scientific advancement

Frontiers in Cellular and Infection Microbiology
Intramuscular vaccines present limitations in eliciting robust mucosal immunity and preventing respiratory pathogens transmission. Sublingual vaccine administration offers promising advantages, including interconnected mucosal protection.
Erwan Sallard, Malik Aydin, Malik Aydin, Malik Aydin   +3 more
doaj   +1 more source

Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

PLoS ONE, 2014
Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA) metastatic ...
Shailbala Singh, Guojun Yang, Kimberly S Schluns, Scott M Anthony, K Jagannadha Sastry   +4 more
doaj   +1 more source

Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability

Allergy, EarlyView.
This study evaluates the effects of heat and pressure autoclaving on peanut proteins, IgE binding, and oral tolerability. Heat and pressure autoclaving breaks down peanut proteins and allergens, contributing to reduced peanut‐specific IgE binding. Autoclaved peanuts are associated with decreased skin test reactivity and greater oral tolerability in ...
Casey G. Cohen, Diana Toscano‐Rivero, Eisha A. Ahmed, Adnan Al Ali, Wei Zhao, Danbing Ke, Duncan Lejtenyi, Liane Beaudette, Hana Chazbey, Abdulaziz S. Alrafiaah, Carmen H. Li, Kurt Dejgaard, Albert M. Berghuis, Bertrand J. Jean‐Claude, Christine McCusker, Thomas Eiwegger, Moshe Ben‐Shoshan, Bruce D. Mazer   +17 more
wiley   +1 more source

Rectal vs. sublingual misoprostol in cesarean section: three‑arm, randomized clinical trial

Caspian Journal of Internal Medicine, 2022
Background: Misoprostol is a myometrial stimulant with uterotonic properties and can be administered rectally, vaginally, or sublingually. Numerous studies have investigated the effect of misoprostol on the prevention and treatment of PPH (postpartum ...
Fatemeh Zahra Bagheri, Mahboobeh Azadehrah, Bizhan Shabankhani, Hooshang Akbari, Ebrahim Nasiri Ferami   +4 more
doaj  

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

New approaches in the treatment of short term and middle of the night insomnia: emerging evidence for a role for sublingual zolpidem tablets. [PDF]

, 2010
Insomnia affects a significant proportion of the general population and an even greater proportion of patients seen in general medical care. Insomnia has multiple negative effects on health status, decreases quality of life, and is associated with ...
Ownby, Raymond L
core   +3 more sources

A One‐Strength Dose Escalation Regimen for Birch Pollen SCIT Is Safe and Tolerable in Children, Adolescents, and Adults

Allergy, EarlyView.
This study evaluated safety and tolerability of birch pollen SCIT during dose escalation with a new One‐Strength regimen (3 injections, Strength B) compared to the Standard regimen (7 injections, Strengths A and B) in patients aged 5–65 years. Safety and tolerability were comparable between the two regimens in adults, adolescents, and adolescents, as ...
Marek Jutel, Ludger Klimek, Michael Gerstlauer, Dana Troyke, Kristina Duwensee, Christian Vogelberg   +5 more
wiley   +1 more source

Sublingual sufentanil, a new opportunity for the improvement of postoperative pain management in Italy [PDF]

, 2016
Despite the availability of national and international guidelines, adequate postoperative pain (POP) management is still a challenge in Italy. One of the potential reasons for the high incidence of surgical patients complaining moderate to severe pain is
COLUZZI, FLAMINIA, Fanelli, A., Sacerdote, P   +2 more
core  

Nicotine-replacement therapy: A proven treatment for smoking cessation [PDF]

, 2010
Smoking is a major cause of cardiovascular diseases, respiratory diseases and cancer. Despite the high prevalence of smokers worldwide, smokers are often neglected and not offered effective assistance with quitting their habits. In order to overcome this
Robson, Noorzurani
core   +1 more source