Results 111 to 120 of about 1,812,803 (254)

Cardiometabolic effects of contrast therapy: A systematic review

open access: yesExperimental Physiology, EarlyView.
Abstract The rising prevalence of overweight and obesity, together with associated cardiometabolic disorders, underscores the need for additional strategies alongside established interventions. The growing popularity of contrast therapy – alternating exposure to heat and cold, a practice common in traditional Finnish sauna bathing – has prompted ...
Veerle de Haan   +2 more
wiley   +1 more source

Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine

open access: yes, 2013
Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.Board of Regents, University of Texas ...
Croyle, Maria A.   +2 more
core   +1 more source

Comparison of exercise training and repeated hot water immersion on vascular function in overweight older adults

open access: yesExperimental Physiology, EarlyView.
Abstract Recent studies suggest that heat exposure may benefit cardiovascular health, but in overweight and obese older adults, the chronic effects of heat therapy on artery function are still uncertain. We aimed to compare the effects of 12 weeks (3×/week, 40 min) of aerobic exercise (EXE) to hot water immersion (HWI) and an inactive control group ...
Juliene G. Costa   +6 more
wiley   +1 more source

Lung‐Cardiovascular Interactions and Derangements in ARDS

open access: yesComprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez   +4 more
wiley   +1 more source

Sublingual Administration of Tacrolimus in Liver Transplant Patient with Intestinal Malabsorption

open access: yesIndian Journal of Transplantation
Immunosuppressive therapy after liver transplantation typically combines a calcineurin inhibitor, an antimetabolite, and corticosteroids. Tacrolimus, due to its narrow therapeutic margin and variability in blood levels, requires therapeutic drug ...
Aritz Merchán Flores   +3 more
doaj   +1 more source

Nanomedicine for the Treatment of Pediatric Type 2 Diabetes: Progress, Challenges, and Translational Perspectives

open access: yesAdvanced Therapeutics, Volume 9, Issue 9, September 2026.
Overview of pharmaceutical nanocarriers in diabetes, illustrating applications of nanotechnology including enhanced drug and targeted drug delivery and nanosensors for glucose monitoring and diagnosis. ABSTRACT Pediatric type 2 diabetes mellitus (T2DM) is rapidly emerging as a critical global health concern, driven largely by rising childhood obesity ...
Nnamdi Ikemefuna Okafor   +2 more
wiley   +1 more source

Establishing Time Course of Testosterone Using Saliva After a Sublingual Administration: A Pilot Study

open access: yes, 2017
Sublingual administration of 0.05 mg of testosterone has been found to be a safe and effective method to induce higher testosterone levels in females.
Strenth, Chance
core  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, Volume 13, Issue 50, 7 September 2026.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

A cross-comparative pharmacokinetic study of Klimalanin (ingestion or sublingual intake)

open access: yesГинекология, 2013
Beta-alanine (Klimalanin) is generally used for the treatment and prevention of vasomotor disturbances (hot flushes) in menopausal period. This paper presents the results of a comparative analysis of the beta-alanine pharmacokinetics with a single ...
I S Yurghel   +7 more
doaj  

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