Results 51 to 60 of about 2,390,183 (202)

An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration

Scientific Reports, 2017
Nonporous silica nanoparticles (SiNPs) have potential as promising carriers for ophthalmic drugs. However, the in vivo safety of ocular topical SiNPs remains unclear.
Martha A. Kim, J. Park, Hyejoong Jeong, Jinkee Hong, Woo Sung Choi, Byung-Han Lee, Choul-Yong Park   +6 more
semanticscholar   +1 more source

Ocular Drug Distribution After Topical Administration: Population Pharmacokinetic Model in Rabbits

European journal of drug metabolism and pharmacokinetics, 2016
Background and ObjectiveWhen eye diseases are treated by topical administration, the success of treatment lies in the effective drug concentration in the target tissue.
N. Djebli, S. Khier, F. Griguer, Anne-Laure Coutant, Alexandra Tavernier, G. Fabre, C. Leriche, D. Fabre   +7 more
semanticscholar   +1 more source

Cardiovascular Complications Resulting from Topical Lidocaine Application

International Journal of Gerontology, 2008
Topical lidocaine is one of the most commonly used anesthetics in the emergency department (ED). The advantages of topical anesthesia include ease of application, minimal discomfort on administration, and rapid onset of anesthesia. Systemic toxic effects
Feng Lin, Wen-Han Chang, Yu-Jang Su, Cheng-Ho Tsai   +3 more
doaj   +1 more source

Topical Administration of Ibuprofen for Injured Athletes: Considerations, Formulations, and Comparison to Oral Delivery

Sports Medicine - Open, 2017
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs commonly used to treat both the acute and chronic injuries sustained by athletes during training and competition. In many parts of the world, NSAIDs can be purchased over-the-counter and
M. Manoukian, C. Migdal, Amode R. Tembhekar, Jerad A. K. Harris, C. Demesa   +4 more
semanticscholar   +1 more source

NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

Journal of Translational Medicine, 2016
Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP).
B. Falsini, G. Iarossi, A. Chiaretti, A. Ruggiero, Manni Luigi, L. Galli‐Resta, G. Corbo, E. Abed   +7 more
semanticscholar   +1 more source

Topical administration of a connexin43‐based peptide augments healing of chronic neuropathic diabetic foot ulcers: A multicenter, randomized trial

Wound Repair and Regeneration, 2015
Nonhealing neuropathic foot ulcers remain a significant problem in individuals with diabetes. The gap‐junctional protein connexin43 (Cx43) has roles in dermal wound healing and targeting Cx43 signalling accelerates wound reepithelialization.
C. Grek, G.M. Prasad, V. Viswanathan, D. Armstrong, R. Gourdie, G. Ghatnekar   +5 more
semanticscholar   +1 more source

Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model

Scientific Reports
Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but is associated with side effects. Topical drug administration effectively minimizes side effects.
Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama   +9 more
doaj   +1 more source

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

PLoS Pathogens, 2015
Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple efforts to prevent HIV transmission are based on pre-exposure prophylaxis with various antiretroviral drugs.
M. Kovárová, Olivia D Council, A. Date, Julie M. Long, Tomonori Nochii, Michael Belshan, A. Shibata, Heather Vincent, Caroline E. Baker, W. Thayer, Guenter Kraus, Sophie Lachaud-Durand, P. Williams, C. Destache, J. Victor Garcia, R. Desrosiers   +15 more
semanticscholar   +1 more source

Polymer-based biomaterials for pharmaceutical and biomedical applications: a focus on topical drug administration

European Polymer Journal, 2023
P. Pires, Filipa Mascarenhas-Melo, Kelly Pedrosa, Daniel Lopes, Joana Lopes, Ana Macário‐Soares, Diana Peixoto, P. Giram, F. Veiga, Ana Cláudia Paiva-Santos   +9 more
semanticscholar   +1 more source

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

Journal of Pharmacological Sciences, 2008
A pain model for screening analgesics was established in anesthetized rats. The omenta of urethane-anesthetized rats were exteriorized, fixed in a plastic chamber, and superfused with Tyrode solution.
Shi-Jie Yang, Makoto Katori, Masataka Majima   +2 more
doaj