Results 41 to 50 of about 4,786,914 (232)

Microneedles enhance the efficacy of topical dental anesthesia in male subjects: a randomized controlled trial [PDF]

open access: yesBrazilian Oral Research
: This study aimed to determine whether microneedles (MN) can enhance the efficacy of a commercially available topical anesthetic (EMLA®) when applied to the palatal mucosa.
Stephany Di Carla Santos   +5 more
doaj   +2 more sources

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

open access: yesPharmaceutics, 2023
Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many ...
Nakamwi Akombaetwa   +5 more
semanticscholar   +1 more source

Topical prostaglandin analogues and conjunctival inflammation in uveitic glaucoma. [PDF]

open access: yes, 2012
20.02.14 KB. Ok to add published verson to spiral, OA paper.A pilot study to determine whether topical prostaglandin analogues alter the expression of conjunctival inflammatory markers in patients with uveitic glaucoma.Prospective, single-masked case ...
Sallam, A   +3 more
core   +1 more source

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay [PDF]

open access: yes, 2008
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy ...
Borelli, Claudia   +5 more
core   +1 more source

Comprehensive ocular and systemic pharmacokinetics of brinzolamide in rabbits after intracameral, topical, and intravenous administration.

open access: yesJournal of Pharmacy and Science, 2020
Brinzolamide is a topical carbonic anhydrase inhibitor which reduces the production of aqueous humor in the ciliary body, thereby reducing intra-ocular pressure. It is formulated as an ophthalmic suspension. Pharmacokinetics of ocular suspensions are not
Vatsala Naageshwaran   +5 more
semanticscholar   +1 more source

Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study [PDF]

open access: yesActa Medica Iranica, 2011
Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids.
Hamid Reza Ghafarian Shirazi   +3 more
doaj   +2 more sources

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

open access: yesJournal of Pharmacological Sciences, 2008
A pain model for screening analgesics was established in anesthetized rats. The omenta of urethane-anesthetized rats were exteriorized, fixed in a plastic chamber, and superfused with Tyrode solution.
Shi-Jie Yang   +2 more
doaj   +1 more source

Essential Oils and Isolated Terpenes in Nanosystems Designed for Topical Administration: A Review

open access: yesBiomolecules, 2019
Essential oils are natural products with a complex composition. Terpenes are the most common class of chemical compounds present in essential oils. Terpenes and the essential oils containing them are widely used and investigated by their pharmacological ...
S. D. de Matos   +4 more
semanticscholar   +1 more source

Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial

open access: yesDentistry Journal, 2023
Local anesthesia is administered to reduce pain-induced stress during dental treatment. However, local anesthetic injections are extremely painful; thus, methods to minimize this pain should be developed. Clinical studies on the pain-relieving effects of
Ryouji Tani   +5 more
doaj   +1 more source

Comparison of intravenous, topical or combined routes of tranexamic acid administration in patients undergoing total knee and hip arthroplasty: a meta-analysis of randomised controlled trials

open access: yesBMJ Open, 2019
Objective This study aimed to compare the effects of intravenous, topical and combined routes of tranexamic acid (TXA) administration on blood loss and transfusion requirements in patients undergoing total knee arthroplasty (TKA) and total hip ...
Qi Sun   +5 more
semanticscholar   +1 more source

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