Results 41 to 50 of about 327,809 (311)

The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty

Journal of Orthopaedic Surgery, 2017
Aims: The combined (IV (intravenous) + topical) use of tranexamic acid (TXA) has been shown to be a safe method and more effective than single (IV or topical) application.
Deniz Cankaya, Uygar Dasar, Ahmet Burak Satilmis, Serdar Hakan Basaran, Mustafa Akkaya, Murat Bozkurt   +5 more
doaj   +1 more source

Novel locally active estrogens accelerate cutaneous wound healing-part 2 [PDF]

, 2017
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds.
Bartoli, Gabriele, Bella, Angela La, Brufani, Mario, Ceccacci, Francesca, Ciana, Paolo, D’Aiuto, Virginia, FILOCAMO, Luigi, LEONELLI, Francesca, Maggi, Adriana, MARINI BETTOLO, Rinaldo, Meda, Clara, MIGNECO, Luisa Maria, Rizzi, Nicoletta   +12 more
core   +2 more sources

Transdermal evaluation of caffeine in different formulations and excipients [PDF]

, 2013
Background: The stratum corneum(SC) forms adifficultphysical barrier fordrugs to pass through the skin. Several strategieswere developed to overcome this barrier.Optimization of topical drug formulations by selected excipients may facilitate the ...
Boonen, Jente, Burvenich, Christian, De Spiegeleer, Bart, Mehuys, Els, Peremans, Kathelijne, Remon, Jean Paul, Roche, Nathalie, Veryser, Lieselotte   +7 more
core   +2 more sources

A Randomized, Double-Blinded, Placebo-Controlled, Cross Over Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine [PDF]

, 2020
Introduction. Daily oral beta-adrenoreceptor antagonist has been shown to be effective in preventing migraine headaches. Timolol 0.5% ophthalmic solution is a non-selective beta-adrenoreceptor antago- nist, where the primary use is for glaucoma.
Aggarwal, Dipika, Barohn, Richard J., Bittel, Brennen, Dubinsky, Richard, Ford, Deetra, Gronseth, Gary, Hairston, Vernita, Heim, Andrew J., Herbelin, Laura, Landazuri, Patrick, Sachen, Fred   +10 more
core   +2 more sources

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Cytotoxicity and effect on wound re‐epithelialization after topical administration of tranexamic acid

BJS Open, 2019
Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off‐label.
T. A. Eikebrokk, B. S. Vassmyr, K. Ausen, C. Gravastrand, O. Spigset, B. Pukstad   +5 more
doaj   +1 more source

Central Serous Chorioretinopathy in a 14-year-old atopic boy: a case report

Italian Journal of Pediatrics, 2023
Background Corticosteroids are widely used in medicine. Few cases of central serous chorioretinopathy (CSC) have been reported following topical corticosteroid administration.
Stefano Ranno, Liviana Fontanel, Edoardo Ruggiero, Paolo Nucci, Paolo Radice, Simone Donati   +5 more
doaj   +1 more source

Restoring Conjunctival Tolerance by Topical Nuclear Factor–κB Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice [PDF]

, 2014
Purpose.: To evaluate the role of nuclear factor–κB (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis.
Gabelloni, María Laura, Galletti, Jeremías Gastón, Giordano, Mirta Nilda, Guzman, Mauricio, Sabbione, Florencia, Trevani, Analía Silvina, Vanzulli, Silvia   +6 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Pharmaceutics, 2018
Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable).
Rinda Devi Bachu, Pallabitha Chowdhury, Zahraa H. F. Al-Saedi, Pradeep K. Karla, Sai H. S. Boddu   +4 more
doaj   +1 more source