Results 41 to 50 of about 4,250,233 (251)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Impact of Contractual Governance on Project Performance in Urban Sewage Treatment Public–Private Partnership Projects: The Moderating Role of Administrative Efficiency

Buildings
In public–private partnership (PPP) projects, the private sector’s performance is influenced by administrative efficiency, and the impact varies across different contractual dimensions.
Jialin Gui, Jinbo Song, Wen Xia
doaj   +1 more source

Relationship of Concepts “Administrative Punishment” and “Administrative Responsibility”

Сибирское юридическое обозрение, 2020
The article discusses the development of a new scientific field – administrative penology, the subject of research of which is aimed at seeking to increase the efficiency of the appointment and execution of administrative punishment.The completeness of ...
A. N. Deryuga, S. N. Shaklein
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Level of competence of the administrative staff at Yarmouk University in light of their demographic differences

Journal of Arts & Social Sciences, 2017
The present study aims at revealing the level of competence of the administrative staff at Yarmouk University. In order to achieve the objective of the study, a population of 291 individuals were randomly selected.
Najwa Darawsha
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Administrative Judiciary in Poland in Search for Fairness and Efficiency - an Overview

Transylvanian Review of Administrative Sciences, 2007
The 2002 reform of Polish administrative judiciary introduced two – instance system of administrative courts. The main aim of the article is to analyze some of the novelties that are to ensure fairness, cohesion and effectiveness of the administrative ...
Andrzej SKOCZYLAS, Mariusz SWORA
doaj   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

National Action Plan for Energy Efficiency, Chapter 6: Energy Efficiency Program Best Practices

, 2006
Chapter from the National Action Plan for Energy Efficiency documenting key findings from energy efficiency programs that have been successfully operating for many ...
National Action Plan for Energy Efficiency (U.S.)
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