Results 51 to 60 of about 134,727 (261)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Technical Efficiency Of Arabian And East African Container Terminals. [PDF]

, 2007
In this paper the efficiency and performance is evaluated the terminal container for 22 seaports in the region of East Africa and the Middle East. The aim of our study is to compare container terminals situated on the maritime trade road between the East
Mustaffa, Adli, Barros, Carlos Pestana, Khader, Ahmad Tajudin, Al-Eraqi, Ahmed Salem   +3 more
core  

Achieving green growth through official accountability: The impact of administrative pressure on green innovation efficiency

Journal of Innovation & Knowledge
Administrative pressure on local officials concerning environmental performance is a pivotal factor influencing regional green development. To explore how such pressure affects green innovation efficiency—a key determinant of competitive sustainability ...
Guoliang Jiang, Fang Zhao, Xing Liu
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Level of competence of the administrative staff at Yarmouk University in light of their demographic differences

Journal of Arts & Social Sciences, 2017
The present study aims at revealing the level of competence of the administrative staff at Yarmouk University. In order to achieve the objective of the study, a population of 291 individuals were randomly selected.
Najwa Darawsha
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Efficiency and Administrative Costs in Primary Care [PDF]

We construct a simple model of the determinants of administrative managerial effort and apply it explain the doubling of the cost of administering primary care in England in real terms between 1989/90 and 1994/5 following the introduction of the internal
Hugh Gravelle, Antonio Giuffrida, Matthew Sutton   +2 more
core  

Efficiency, legitimacy, and the administrative state

, 2021
This essay examines certain epistemic problems facing administrative states' efforts to draft efficient regulations for their societies. I argue that a basic feature of the administrative state's authority, namely its monopoly over the production of ...
DeCanio, Samuel
core   +1 more source

THE ROLE OF SALES ADMIN IN SUPPORTING ADMINISTRATIVE EFFICIENCY FOR SALES MARKETING DEPARTMENT PERFORMANCE AT NOVOTEL SEMARANG

Journal of Management Small and Medium Enterprises (SME's)
This study examines the role of Sales Admin in supporting administrative efficiency for Sales Marketing Department performance at Novotel Semarang.
Adinda Consita Yulianne Prabowo, Yuniarto R Satato   +1 more
doaj   +1 more source