Results 11 to 20 of about 2,066 (126)

Association between early‐life farming exposure and Alzheimer's disease neuropathological burden [PDF]

Alzheimers Dement
Abstract BACKGROUND Farming populations may face a disproportionate share of adverse exposures influencing Alzheimer's disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early‐life exposure is related to AD neuropathology is limited.
Powell W, Melcher E, Otte R, Lim S, Etter L, Pfaff A, DeWitt A, Lee A, Ketchum F, Salamat M, Bradfield C, Goutman S, Zuelsdorff M, Bakulski K, Rissman R.   +14 more
europepmc   +2 more sources

Transient visual evoked potential abnormalities in ADNP syndrome [PDF]

Journal of Neurodevelopmental Disorders
Background ADNP syndrome is a rare genetic disorder associated with global developmental delay/intellectual disability, autism, aberrant behavior, and medical comorbidities. Sensory symptoms represent a core clinical feature, even in those without autism
Tess Levy, Hailey Silver, Nurit Benrey, Abigail Siegel, Christina Layton, Vance Zemon, James Gordon, Joseph D. Buxbaum, Alexander Kolevzon, Paige M. Siper   +9 more
doaj   +2 more sources

ADNP regulates chromatin architecture and lineage fidelity during neural differentiation. [PDF]

PLoS Genetics
Transition from a pluripotent to a differentiated cell state is accompanied by significant changes in genome organization. Activity dependent neuroprotective protein (ADNP) is a chromatin regulator with critical roles in neurodevelopment and limits the ...
Phillip Wulfridge, Nathaniel Rell, John Doherty, Kuo-Chen Fang, Michelle Lee Lynskey, Kavitha Sarma   +5 more
doaj   +2 more sources

ADNP missense variant p.C687R disrupts chromatin regulation and GABAergic differentiation in Helsmoortel–Van der Aa syndrome [PDF]

Molecular Autism
Background Activity-dependent neuroprotective protein (ADNP) is a critical regulator of neurodevelopment, and most pathogenic variants reported in Helsmoortel–Van der Aa syndrome (HVDAS) are truncating variants.
Qi Chen, Xixi Liu, Mengnan Wu, Daijing Sun, Xingyu Ding, Mengling Zhou, Wenzhu Peng, Yan Cheng, Biqing Xue, Ning Tang, Gang Xu, Yilin Tai, Qiong Xu, Man Xiong, Yan Jiang   +14 more
doaj   +2 more sources

Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population [PDF]

Frontiers in Immunology
BackgroundBeyond the role of neutralizing antibodies in protecting against SARS-CoV-2, Fc-mediated antibodies functions may offer additional immune defense.
Mingzhi Gan, Mingzhi Gan, Weiwei Han, Chuang Li, Simin Li, Zhuangzhuang Huang, Lingjie Xu, Xiaoyu Xu, Xiangjun Zhai, Xiangjun Zhai, Yuxin Chen, Jingxin Li, Jingxin Li   +12 more
doaj   +2 more sources

A protein-based pneumococcal vaccine elicits broad immunity associated with multifunctional antibody responses in humans [PDF]

The Journal of Clinical Investigation
Traditional polysaccharide vaccines are constrained by streptococcus pneumoniae diversity. We propose a protein-based pneumococcal vaccine (PBPV) — formulated with conserved surface proteins P3296, P5668, PRx1, and pneumolysin (Ply) — that could ...
Kaiyi Li, Jinglu Yang, Xiaobing Zhai, Jinbo Gou, Xiuwen Sui, Bochao Wei, Yuan Wang, Xiaoling Su, Xiaoyun Yang, Shiqin Jin, Xuan Zhou, Yuxuan Zhang, Tao Zhu, Junxiang Wang, Zhongfang Wang   +14 more
doaj   +2 more sources

Systemic davunetide provides sex-specific neuroprotection during Coronary Artery Bypass Grafting (CABG) [PDF]

Translational Psychiatry
Coronary artery bypass grafting (CABG) is a surgical procedure commonly employed to treat severe coronary artery disease by improving blood flow to the heart.
Illana Gozes, Jason Blatt, Liri S. Guz
doaj   +2 more sources

Coronavac inactivated vaccine triggers durable, cross-reactive Fc-mediated phagocytosis activities

Emerging Microbes and Infections, 2023
Although humoral responses elicited by infection or vaccine lost the ability to prevent transmission against Omicron, vaccine-induced antibodies may still contribute to disease attenuation through Fc-mediated effector functions.
Lili Wang, Chuang Li, Wanting Li, Liwei Zhao, Tiantian Zhao, Lin Chen, Ming Li, Jing Fan, Jiayan Li, Chao Wu, Yuxin Chen   +10 more
doaj   +1 more source

Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation. [PDF]

PLoS ONE, 2014
Tauopathy, a major pathology in Alzheimer's disease, is also found in ~50% of frontotemporal dementias (FTDs). Tau transcript, a product of a single gene, undergoes alternative splicing to yield 6 protein species, each with either 3 or 4 microtubule ...
Yulie Schirer, Anna Malishkevich, Yotam Ophir, Jada Lewis, Eliezer Giladi, Illana Gozes   +5 more
doaj   +1 more source

ADNP: In search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration

Frontiers in Aging Neuroscience, 2015
Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer’s disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social ...
Illana eGozes, Yanina eIvashko-Pachima
doaj   +1 more source