Results 141 to 150 of about 1,062,201 (314)

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

The natural virtues in adolescence

, 1952
E.F Bown
openalex   +1 more source

Seafood Consumption during Childhood and Adolescence and Neurocognitive Development: A Systematic Review [PDF]

, 2020
Linda Snetselaar, Regan L Bailey, Joan Sabaté, Linda Van Horn, Barbara O. Schneeman, Joanne Spahn, Julia Kim, Charlotte Bahnfleth, Gisela Butera, Nancy Terry, Julie Obbagy   +10 more
openalex   +1 more source

Maternal and neonatal outcomes of in-water and out-of-water births in low-obstetric-risk labour: a retrospective observational study at Piacenza hospital.

Journal of Biomedical Practitioners
INTRODUCTION The utilisation of birth pool immersion during labour and delivery constitutes one of the primary non-pharmacological methods for alleviating pain.
Elisa Piccolo, Giacomo Biasucci, Mariasole Magistrali, Belinda Benenati, Daniela Russo, Marina Paola Mercati, Sonia Tesoriati, Marina Cicalla, Simona Illari, Cristiana Pavesi, Maurizio Beretta, Marina Bolzoni   +11 more
doaj   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Additional file 2: of Epigenome-wide association study of asthma and wheeze in childhood and adolescence

, 2017
Ryan Arathimos, Matthew Suderman, Gemma C. Sharp, Kimberley Burrows, Raquel Granell, Kate Tilling, Tom R. Gaunt, John Henderson, Susan M. Ring, Rebecca C. Richmond, Caroline L. Relton   +10 more
openalex   +1 more source

El tiempo de la adolescencia. Algunas reflexiones surgidas del proyecto de investigación: El pasaje al acto y el acting out: presentaciones del malestar adolescente de la época. Su diferencia con el síntoma ; The time of adolescence. Reflections from the research project: The passage to the act and the acting out: presentations of the adolescent suffering at this time. Its difference with the symptom [PDF]

, 2022
Ana Lucía Soler, Fiorella Garnero, Elba Beatriz Lauc   +2 more
openalex  

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source