Results 61 to 70 of about 7,389,456 (292)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Adoptive cell therapy for HBV-associated liver diseases

Biomedical Technology
Chronic infection with the hepatitis B virus (HBV) is a common cause of liver disease worldwide, particularly in Asia and Africa, where it is highly prevalent.
Youxi Zhou, Kaizhao Chen, Yang Zhang, Hongwei Cheng, Shuaishuai Zhang   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Engineering T cells to improve the efficacy and safety of adoptive T-cell therapy [PDF]

, 2021
Adoptive T-cell therapy utilizing chimeric antigen receptors (CARs) has shown multiple successes in treating certain hard-to-treat blood cancers, leading to five CAR T-cell therapies approved by the FDA for leukemia, lymphoma, and multiple myeloma ...
Nam, Eunwoo
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Prospectives of T-cells genetic programming in adoptive immunotherapy of malignancies

Сеченовский вестник, 2016
The article reviews the literature on adoptive T-cell therapy of malignancies. Adoptive T-cell transfer allows treatment of metastatic disease on the late stages of certain tumors.
O. L. Morozova, V. V. Yakovlev, N. A. Sushentsev   +2 more
doaj  

Regional and intratumoral adoptive T-cell therapy

Immuno-Oncology and Technology
Adoptive T-cell therapies (ACTs) including tumor-infiltrating lymphocytes and engineered T cells (transgenic T-cell receptor and chimeric antigen receptor T cells), have made an important impact in the field of cancer treatment over the past years.
I. Olivera, I. Etxeberria, C. Luri-Rey, P. Molero-Glez, I. Melero   +4 more
doaj   +1 more source

Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy

Journal of Biological Engineering, 2021
Bioreactors are essential tools for the development of efficient and high-quality cell therapy products. However, their application is far from full potential, holding several challenges when reconciling the complex biology of the cells to be expanded ...
Oscar Fabian Garcia-Aponte, Christoph Herwig, Bence Kozma   +2 more
doaj   +1 more source

Adopting tomorrow's therapies today: a perspective review of adoptive cell therapy in lung cancer. [PDF]

Ther Adv Med Oncol
Lung cancer is the leading cause of all cancer-related deaths in the United States and remains a global health challenge. While targeted therapy has revolutionized the treatment landscape of nonsmall cell lung cancer, many patients lack actionable mutations.
Abodunrin F, Olson DJ, Emehinola O, Bestvina CM.   +3 more
europepmc   +5 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source