Results 51 to 60 of about 7,389,456 (292)

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy [PDF]

, 2017
Adoptive cell therapy holds much promise in the treatment of cancer but results in solid tumors have been modest. The notable exception is tumor-infiltrating lymphocyte (TIL) therapy of melanoma, but this approach only works with high-dose ...
João Manuel Santos, Anja Ehrhardt, Nettelbeck, Dirk M., Tähtinen, Siri, Dirk M. Nettelbeck, Anna Kanerva, Karell, Pauliina, Susanna Grönberg-Vähä-Koskela, Pauliina Karell, Mikko Siurala, Riikka Havunen, Siurala, Mikko, Santos, Joao Manuel, Gronberg-Vaha-Koskela, Susanna, Havunen, Riikka, Ehrhardt, Anja, Juuso Rusanen, Michael Behr, Rusanen, Juuso, Siri Tähtinen, Suvi Sorsa, Kanerva, Anna, Behr, Michael, Sorsa, Suvi, Hemminki, Akseli, Akseli Hemminki   +25 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Innovative approaches of adoptive immune cell therapy in pediatric recipients of ematomopietic stem cell transplantation [PDF]

, 2004
Adoptive immune cell therapy represents one of the most promising fields of investigation in allogeneic haematopoietic stem cell transplantation (allo-HSCT).
MACCARIO R., LOCATELLI, FRANCO, ROSSI F, DAUDT L, COMOLI P, MONTAGNA, DANIELA   +5 more
core   +2 more sources

Adoptive immune cell therapy for colorectal cancer

Frontiers in Immunology
Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide, with limited options for patients at advanced stages. Immunotherapy, particularly immune cell-based therapies, has gained significant attention as an innovative
Chenxiao Liu, Nan Liu, Nan Liu, Tongcun Zhang, Tongcun Zhang, Yanyang Tu, Yanyang Tu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy

Journal of Translational Medicine, 2011
The field of cellular therapy of cancer is moving quickly and the issues involved with its advancement are complex and wide ranging. The growing clinical applications and success of adoptive cellular therapy of cancer has been due to the rapid evolution ...
Stroncek David F, O'Shea John J, Melief Cornelis JM   +2 more
doaj   +1 more source

Decreased tumor surveillance after adoptive T-cell therapy

, 2007
The effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis ...
Mumprecht, Sabine, Ochsenbein, Adrian F., Pinschewer, Daniel D, Bruno Eschli, Pavelic, Viktor, Matter, Matthias, Eschli, Bruno, Matthias Matter, Tsanan Giroglou, von Laer, Dorothee, Ochsenbein, Adrian F, Daniel D. Pinschewer, Adrian F. Ochsenbein, Dorothee von Laer, Sabine Mumprecht, Pinschewer, Daniel D., Giroglou, Tsanan, Viktor Pavelic, Mumprecht S, Ochsenbein AF, Giroglou T, Pinschewer DD, von Laer D, Ochsenbein, Adrian, Eschli B, Pavelic V, Matter M   +26 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

CAR-T Cell Performance: How to Improve Their Persistence?

Frontiers in Immunology, 2022
Adoptive cell therapy with T cells reprogrammed to express chimeric antigen receptors (CAR-T cells) has been highly successful in patients with hematological neoplasms. However, its therapeutic benefits have been limited in solid tumor cases.
Gina López-Cantillo, Claudia Urueña, Bernardo Armando Camacho, Cesar Ramírez-Segura, Cesar Ramírez-Segura   +4 more
doaj   +1 more source

At the Bench: Adoptive cell therapy for melanoma [PDF]

Journal of Leukocyte Biology, 2014
AbstractThe cellular and molecular principles that furnish the foundation for ACT of melanoma and their implications for further clinical research are reviewed. The parallel advances in basic immunology, preclinical animal studies, and clinical trials over the last two decades have been integrated successfully with improvements in technology to produce
openaire   +2 more sources