Results 121 to 130 of about 65,713 (156)
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2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
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The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
openaire +1 more source
Adoptive Cell Transfer Therapy For Malignant Gliomas
2012To date, various adoptive immunotherapies have been attempted for treatment of malignant gliomas using nonspecific and/or specific effector cells. Since the late 1980s, with the development of rIL-2, the efficacy of lymphokine-activated killer (LAK) cell therapy with or without rIL-2 for malignant gliomas had been tested with some modifications in ...
Eiichi, Ishikawa +3 more
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Induction of Tolerance by Adoptive Transfer of Treg Cells
2007Naturally arising CD4+CD25+ regulatory T (Treg) cells can be exploited to establish immunologic tolerance to allogeneic transplants. In vivo exposure of CD4+CD25+ T cells from normal naive mice to alloantigen in a T cell-deficient environment elicits spontaneous expansion of alloantigen-specific CD4+CD25+ natural Treg cells, which are able to suppress ...
Kanji, Nagahama +2 more
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T-cell–based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition
Cancer Immunology Research, 2015Abstract Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell–based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different
Houot, Roch +3 more
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General Approach to Adoptive Transfer and Cell Labeling for Immunoimaging
Cold Spring Harbor Protocols, 2011INTRODUCTIONImaging the single-cell dynamics of the immune system within an intact environment requires the ability to look deep inside tissues and organisms with spatial and temporal resolutions adequate to track cell morphology, motility, and signaling processes, all while minimizing perturbation of the system under study. Fluorescence techniques are
Melanie P, Matheu +2 more
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The use of endogenous T cells for adoptive transfer
Immunological Reviews, 2013SummaryAdoptive T‐cell therapy involves the ex vivo enrichment and expansion of tumor‐reactive T cells for infusion. As an immune‐based approach, adoptive therapy has become an increasingly attractive modality for the treatment of patients with cancer due to its potential for high specificity, non‐cross resistance with conventional therapies, and ...
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Adoptive Transfer of Immunologically Competent Cells
The Journal of Immunology, 1966Summary Adoptive transfer of a primary agglutinin response to sheep erythrocytes by spleen cells given to cyclophosphamide pretreated mice was studied. Various syngeneic, parent-to-hybrid and allogeneic donor-host combinations were investigated.
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Generating natural killer cells for adoptive transfer: expanding horizons
Cytotherapy, 2021Michael O'Dwyer +2 more
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