Results 1 to 10 of about 64,900 (214)

Is It Feasible to Use CMV-Specific T-Cell Adoptive Transfer as Treatment Against Infection in SOT Recipients? [PDF]

Frontiers in Immunology, 2021
During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have ...
Estéfani García-Ríos, Marcos Nuévalos, Francisco J. Mancebo, Pilar Pérez-Romero   +3 more
doaj   +4 more sources

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting

Pharmaceutics, 2020
Adoptive cell transfer therapy is a promising anti-tumor immunotherapy in which effector immune cells are transferred to patients to treat tumors. However, one of its main limitations is the inefficient trafficking of inoculated effector cells to the ...
Laura Sanz-Ortega, José Manuel Rojas, Domingo F. Barber   +2 more
doaj   +3 more sources

Efficient T cell adoptive transfer in lymphoreplete hosts mediated by transient activation of Stat5 signaling [PDF]

Molecular Therapy, 2023
Tennant MD, New C, Ferreira LMR, O'Neil RT.   +3 more
exaly   +2 more sources

Adoptive Cellular Transfer Immunotherapies for Cancer

Cancer Treatment and Research Communications, 2022
Patients with cancer require efficient treatment approaches as the mortality rate due to their disease is high. Conventional therapies, like chemotherapy and radiation, have severe side effects.
Panagiotis Parsonidis, Ioannis Papasotiriou   +1 more
doaj   +1 more source

Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes

OncoImmunology, 2021
The optimization of adoptive transfer approaches of anti-tumor T cells requires both the functional improvement of the injected T cells and the modulation of the tumor microenvironment, favoring the recruitment of these T cells and their activation.
L Marotte, M Capitao, C Deleine, T Beauvais, G Cadiou, J. Perrin, M Chérel, E Scotet, Y Guilloux, F Bruchertseifer, A Morgenstern, A Jarry, J. Gaschet, N Labarriere   +13 more
doaj   +1 more source

Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques. [PDF]

PLoS ONE, 2008
Thus far, live attenuated SIV has been the most successful method for vaccinating macaques against pathogenic SIV challenge; however, it is not clear what mechanisms are responsible for this protection.
Justin M Greene, Benjamin J Burwitz, Alex J Blasky, Teresa L Mattila, Jung Joo Hong, Eva G Rakasz, Roger W Wiseman, Kim J Hasenkrug, Pamela J Skinner, Shelby L O'Connor, David H O'Connor   +10 more
doaj   +1 more source

Adoptive immune transfer from donors offers Anti-HBV protection to HBsAb-negative patients after Allo-HSCT

iScience, 2023
Summary: Adoptive transfer of hepatitis B virus (HBV) immunity may occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we investigated the adoptive transfer of HBV immunity in 112 patients without HBV surface antibody ...
Jinhua Ren, QiaoXian Lin, Qi Chen, Jingjing Xu, Dabin Chen, Renli Chen, Kangni Lin, Haojie Zhu, Chenjing Ye, Xiaofeng Luo, Shaozhen Chen, Hui Kong, Qiong Lin, Nan Li, Xu Lin, Zhizhe Chen, Jianda Hu, Ting Yang   +17 more
doaj   +1 more source

A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. [PDF]

PLoS ONE, 2014
Immunotherapies such as adoptive transfer of T cells or natural killer cells, or monoclonal antibody (MoAb) treatment have recently been recognized as effective means to treat cancer patients.
Tatsuya Moutai, Hideyuki Yamana, Takuya Nojima, Daisuke Kitamura   +3 more
doaj   +1 more source

Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells. [PDF]

PLoS ONE, 2015
We previously described that in a rat model of heart transplantation tolerance was dependent on CD8+CD45RClow Tregs that over-expressed fibrinogen-like protein 2 (FGL2)/fibroleukin. Little is known on the immunoregulatory properties of FGL2.
Séverine Bézie, Elodie Picarda, Laurent Tesson, Karine Renaudin, Justine Durand, Séverine Ménoret, Emmanuel Mérieau, Elise Chiffoleau, Carole Guillonneau, Lise Caron, Ignacio Anegon   +10 more
doaj   +1 more source

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. [PDF]

PLoS ONE, 2012
Both nature and induced regulatory T (Treg) lymphocytes are potent regulators of autoimmune and allergic disorders. Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cell-mediated ...
Wei Xu, Qin Lan, Maogen Chen, Hui Chen, Ning Zhu, Xiaohui Zhou, Julie Wang, Huimin Fan, Chun-Song Yan, Jiu-Long Kuang, David Warburton, Dieudonnée Togbe, Bernhard Ryffel, Song-Guo Zheng, Wei Shi   +14 more
doaj   +1 more source