Results 11 to 20 of about 64,900 (214)
Cell Communication and Signaling, 2023 Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castration-resistant prostate cancer (CRPC).
Rydell Alvarez-Arzola +10 more
doaj +1 more source
Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model. [PDF]
PLoS ONE, 2015 Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy.
Daniel L Galvan +6 more
doaj +1 more source
Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases
iScience, 2020 Summary: Complications after vaccination, lack of vaccines against certain infections, and the emergence of antibiotic-resistant microorganisms point to the need for alternative ways of protection and treatment of infectious diseases. Here, we proposed a
Anastasiia A. Kalinina +8 more
doaj +1 more source
iScience, 2020 Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque +10 more
doaj +1 more source
Impact of interleukin-7 on the differentiation and anti-tumor capabilities of CD8+ T cells [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2020 Background: Developing optimal strategies for generating T cells capable of effectively controlling tumors is one of the most important prerequisites for the clinical application of adoptive cell therapies in cancer patients.
Abdelaziz Zidan, Muobarak Tuorkey
doaj +1 more source
Immune cell labelling and tracking: implications for adoptive cell transfer therapies
EJNMMI Radiopharmacy and Chemistry, 2021 Background The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer.
Filippo Galli +5 more
doaj +1 more source
Adoptive Transfer of Memory B Cells
Bio-Protocol, 2015 The adoptive transfer of antigen-specific B cells into mice that cannot recognize that specific antigen has two main advantages. The first is determining exactly when the B cells were transferred and exposed to antigen.
Griselda Zuccarino-Catania +1 more
doaj +1 more source
Frontiers in Immunology, 2023 Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic
Vianca V. Vianzon +4 more
doaj +1 more source
Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models. [PDF]
PLoS ONE, 2013 INTRODUCTION: Cytokine-induced killer cells (CIK cells) are a heterogeneous subset of ex-vivo expanded T lymphocytes which are characterized with a MHC-unrestricted tumor-killing activity and a mixed T-NK phenotype.
Shujing Shi +5 more
doaj +1 more source
Biomaterials Research, 2022 Aims The alternatively activated macrophages have shown a cardioprotective effect in heart failure. However, the effect of M2 adoptive transfer in non-ischemic heart failure is unknown.
Yihai Liu +4 more
doaj +1 more source