Results 211 to 220 of about 63,665 (250)

Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells. [PDF]

J Immunol
Nguyen AT, Fong KD, Ravesloot-Chavez MM, Pham V, Calderon J, McSorley SJ.   +5 more
europepmc   +1 more source

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Adoptive transfer of T-cell immunity

Trends in Immunology, 2002
Abstract Allogeneic transplantation is the most successful form of T-cell-based cancer immunotherapy to date. However, a major complication of allogeneic transplantation remains the occurrence of graft-versus-host disease (GVHD). Two recent developments might lead to procedures for the induction of strong tumor-specific T-cell immunity without these ...
Helmut W H G, Kessels, Monika C, Wolkers, Ton N M, Schumacher   +2 more
exaly   +6 more sources

Adoptive cell transfer in autoimmune hepatitis

Expert Review of Gastroenterology & Hepatology, 2015
Adoptive cell transfer is an intervention in which autologous immune cells that have been expanded ex vivo are re-introduced to mitigate a pathological process. Tregs, mesenchymal stromal cells, dendritic cells, macrophages and myeloid-derived suppressor cells have been transferred in diverse immune-mediated diseases, and Tregs have been the focus of ...
Albert J Czaja
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Adoptive cell transfer therapy for melanoma

Experimental Dermatology, 2022
AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an example of the most successful cancer immune therapy. It achieves a durable complete response about ~20% of patients, and they might be cured. However, the ratio of patients with durable benefits is not high, and its complicated procedure prevents its ...
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Adoptive T-cell Transfer in Melanoma

Immunotherapy, 2012
Immunotherapy holds a highly promising treatment approach for metastatic melanoma patients. Adoptive cell transfer (ACT) involves the ex vivo expansion of autologous antitumor reactive lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration.
Orit, Itzhaki, Daphna, Levy, Dragoslav, Zikich, Avraham J, Treves, Gal, Markel, Jacob, Schachter, Michal J, Besser   +6 more
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Adoptive T‐cell transfer in cancer immunotherapy

Immunology & Cell Biology, 2006
Adoptive T‐cell therapy has definite clinical benefit in relapsed leukaemia after allogeneic transplant and in Epstein–Barr virus‐associated post‐transplant lymphoproliferative disease. However, the majority of tumour targets are weakly immunogenic self‐antigens and success has been limited in part by inadequate persistence and expansion of transferred
Tey, Siok-Keen, Bollard, Catherine M., Heslop, Helen E.   +2 more
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Isolation of Immune Cells for Adoptive Transfer

2017
Adoptive transfer of T lymphocytes is a useful technique to characterize the role of the immune system in hypertension and vascular disease. Here we describe as an example the isolation of splenic T regulatory cells from donor mice processed to obtain a single cell suspension, followed by negative and positive selection to obtain CD4+ T cells and CD4 ...
Tlili, Barhoumi, Pierre, Paradis, Koren K, Mann, Ernesto L, Schiffrin   +3 more
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Transiently redirected T cells for adoptive transfer

Cytotherapy, 2011
T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy.We describe the pre-clinical evaluation of a method based on transient ...
Hilde, Almåsbak, Edith, Rian, Hanna Julie, Hoel, Martin, Pulè, Sébastien, Wälchli, Gunnar, Kvalheim, Gustav, Gaudernack, Anne-Marie, Rasmussen   +7 more
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Adoptive T Cell Transfer

2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer, Conrad Russell Y. Cruz, Cliona M. Rooney   +2 more
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Adoptive Cell Transfer Therapy For Malignant Gliomas

2012
To date, various adoptive immunotherapies have been attempted for treatment of malignant gliomas using nonspecific and/or specific effector cells. Since the late 1980s, with the development of rIL-2, the efficacy of lymphokine-activated killer (LAK) cell therapy with or without rIL-2 for malignant gliomas had been tested with some modifications in ...
Eiichi, Ishikawa, Shingo, Takano, Tadao, Ohno, Koji, Tsuboi   +3 more
openaire   +2 more sources