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T Cell Receptors for Gene Transfer in Adoptive T Cell Therapy
Critical Reviews in Immunology, 2019The past decade has seen enormous progress in cancer immunotherapy. Checkpoint inhibitors are a class of immunotherapy that act to recruit endogenous T cells of a patient's immune system against cancer-associated peptide- MHC antigens. In this process, mutated antigenic peptides referred to as neoantigens often serve as the target on cancer cells that ...
Preeti Sharma, David M. Kranz
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The use of endogenous T cells for adoptive transfer
Immunological Reviews, 2013SummaryAdoptive T‐cell therapy involves the ex vivo enrichment and expansion of tumor‐reactive T cells for infusion. As an immune‐based approach, adoptive therapy has become an increasingly attractive modality for the treatment of patients with cancer due to its potential for high specificity, non‐cross resistance with conventional therapies, and ...
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Isolation of Immune Cells for Adoptive Transfer
2017Adoptive transfer of T lymphocytes is a useful technique to characterize the role of the immune system in hypertension and vascular disease. Here we describe as an example the isolation of splenic T regulatory cells from donor mice processed to obtain a single cell suspension, followed by negative and positive selection to obtain CD4+ T cells and CD4 ...
Ernesto L. Schiffrin +3 more
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Adoptive cell transfer in autoimmune hepatitis
Expert Review of Gastroenterology & Hepatology, 2015Adoptive cell transfer is an intervention in which autologous immune cells that have been expanded ex vivo are re-introduced to mitigate a pathological process. Tregs, mesenchymal stromal cells, dendritic cells, macrophages and myeloid-derived suppressor cells have been transferred in diverse immune-mediated diseases, and Tregs have been the focus of ...
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Treatment of Subcutaneous Tumor with Adoptively Transferred T Cells
Cellular Immunology, 1997Adoptive immunotherapy with T cells directed at tumor antigens has been demonstrated to result in the regression of malignant tumors in humans. These encouraging results have prompted the further exploration of parameters necessary to treat tumor in various locations in animal models.
John C. Krauss, Liaomin Peng, Suyu Shu
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Induction of Tolerance by Adoptive Transfer of Treg Cells
2007Naturally arising CD4+CD25+ regulatory T (Treg) cells can be exploited to establish immunologic tolerance to allogeneic transplants. In vivo exposure of CD4+CD25+ T cells from normal naive mice to alloantigen in a T cell-deficient environment elicits spontaneous expansion of alloantigen-specific CD4+CD25+ natural Treg cells, which are able to suppress ...
Shimon Sakaguchi +2 more
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Establishing T Cell Memory by Adoptive Transfer of T Cell Clones.
Blood, 2006Abstract Adoptive transfer of T cells has been employed to reconstitute T cell immunity to viruses such as cytomegalovirus (CMV) in immunodeficient allogeneic stem cell transplant (SCT) patients and is being investigated to treat malignancies.
Carolina Berger +3 more
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Manipulating the tumor microenvironment by adoptive cell transfer of CAR T-cells
Mammalian Genome, 2018T-cells expressing synthetic chimeric antigen receptors (CARs) have revolutionized immuno-oncology and highlighted the use of adoptive cell transfer, for the treatment of cancer. The phenomenal clinical success obtained in the treatment of hematological malignancies with CAR T-cells has not been reproduced in the treatment of solid tumors, mainly due ...
Kavitha Gowrishankar +2 more
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Adoptive Cell Transfer Therapy For Malignant Gliomas
2012To date, various adoptive immunotherapies have been attempted for treatment of malignant gliomas using nonspecific and/or specific effector cells. Since the late 1980s, with the development of rIL-2, the efficacy of lymphokine-activated killer (LAK) cell therapy with or without rIL-2 for malignant gliomas had been tested with some modifications in ...
Eiichi Ishikawa +3 more
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Adoptive transfer of transgenic T cells to study mucosal adjuvants
Methods, 2009The study of the initiation and regulation of T-cell responses to vaccine antigens is of primary importance in the rational design of mucosal adjuvants. The detection in vivo of T-cell priming following immunization can be performed by using the adoptive transfer model of naïve antigen-specific transgenic T cells into immunocompetent mice. In this work,
PETTINI E. +3 more
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