Results 301 to 310 of about 109,574 (350)

Characterization of human MHC II-restricted T cell receptors with reactivity against B cells and tumor cells for therapeutic application in the context of adoptive T cell transfer of transgenic CD4 T cells

, 2011
Luise Weigand
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Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis. [PDF]

Arthritis Res Ther
Liu Y, Wang XQ, Lu JH, Huang HW, Qiu YH, Peng YP.   +5 more
europepmc   +1 more source

Hemorrhagic autoimmune encephalomyelitis induced by adoptive transfer of activated semiallogeneic spleen cells into irradiated rats.

, 1988
Y Matsumoto, Kazuhiro Kawai, M Fujiwara
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Adoptive cell transfer therapy for melanoma

Experimental Dermatology, 2022
AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an example of the most successful cancer immune therapy. It achieves a durable complete response about ~20% of patients, and they might be cured. However, the ratio of patients with durable benefits is not high, and its complicated procedure prevents its ...
openaire   +2 more sources

Adoptive transfer of T-cell immunity

Trends in Immunology, 2002
Abstract Allogeneic transplantation is the most successful form of T-cell-based cancer immunotherapy to date. However, a major complication of allogeneic transplantation remains the occurrence of graft-versus-host disease (GVHD). Two recent developments might lead to procedures for the induction of strong tumor-specific T-cell immunity without these ...
Helmut W H G, Kessels, Monika C, Wolkers, Ton N M, Schumacher   +2 more
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Adoptive T-cell Transfer in Melanoma

Immunotherapy, 2012
Immunotherapy holds a highly promising treatment approach for metastatic melanoma patients. Adoptive cell transfer (ACT) involves the ex vivo expansion of autologous antitumor reactive lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration.
Orit, Itzhaki, Daphna, Levy, Dragoslav, Zikich, Avraham J, Treves, Gal, Markel, Jacob, Schachter, Michal J, Besser   +6 more
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Transiently redirected T cells for adoptive transfer

Cytotherapy, 2011
T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy.We describe the pre-clinical evaluation of a method based on transient ...
Hilde, Almåsbak, Edith, Rian, Hanna Julie, Hoel, Martin, Pulè, Sébastien, Wälchli, Gunnar, Kvalheim, Gustav, Gaudernack, Anne-Marie, Rasmussen   +7 more
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Adoptive T Cell Transfer

2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer, Conrad Russell Y. Cruz, Cliona M. Rooney   +2 more
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Adoptive T‐cell transfer in cancer immunotherapy

Immunology & Cell Biology, 2006
Adoptive T‐cell therapy has definite clinical benefit in relapsed leukaemia after allogeneic transplant and in Epstein–Barr virus‐associated post‐transplant lymphoproliferative disease. However, the majority of tumour targets are weakly immunogenic self‐antigens and success has been limited in part by inadequate persistence and expansion of transferred
Tey, Siok-Keen, Bollard, Catherine M., Heslop, Helen E.   +2 more
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