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Imaging Adoptive Cell Transfer Based Cancer Immunotherapy
Current Pharmaceutical Biotechnology, 2010The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular and cellular mechanisms of immune ...
Brian A, Rabinovich, Caius G, Radu
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Adoptive cell transfer in autoimmune hepatitis
Expert Review of Gastroenterology & Hepatology, 2015Adoptive cell transfer is an intervention in which autologous immune cells that have been expanded ex vivo are re-introduced to mitigate a pathological process. Tregs, mesenchymal stromal cells, dendritic cells, macrophages and myeloid-derived suppressor cells have been transferred in diverse immune-mediated diseases, and Tregs have been the focus of ...
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T-cell–based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition
Cancer Immunology Research, 2015Abstract Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell–based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different
Houot, Roch +3 more
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Adoptive Cell Transfer Therapy For Malignant Gliomas
2012To date, various adoptive immunotherapies have been attempted for treatment of malignant gliomas using nonspecific and/or specific effector cells. Since the late 1980s, with the development of rIL-2, the efficacy of lymphokine-activated killer (LAK) cell therapy with or without rIL-2 for malignant gliomas had been tested with some modifications in ...
Eiichi, Ishikawa +3 more
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Isolation of Immune Cells for Adoptive Transfer
2017Adoptive transfer of T lymphocytes is a useful technique to characterize the role of the immune system in hypertension and vascular disease. Here we describe as an example the isolation of splenic T regulatory cells from donor mice processed to obtain a single cell suspension, followed by negative and positive selection to obtain CD4+ T cells and CD4 ...
Tlili, Barhoumi +3 more
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Functions of C2D macrophage cells after adoptive transfer
Journal of Leukocyte Biology, 2007AbstractMacrophage function depends on their in situ location. To test this hypothesis, we examined functional changes of the C2D macrophage cell line after adoptive transfer. In vitro, C2D macrophages reside early in the macrophage lineage and show little functional activity. After in vivo i.p.
Betsey E, Potts, Stephen K, Chapes
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Th1 CD4+Cells Adoptively Transfer Experimental Hypersensitivity Pneumonitis
Cellular Immunology, 1997Cultured cells from Micropolyspora faeni-sensitized donors can adoptively transfer murine experimental hypersensitivity pneumonitis (EHP). To determine whether the CD4+ cells responsible for transfer have characteristics of Th1 or Th2 cells, we established cell lines from lung-associated lymph nodes of M. faeni-sensitized C3H/HeJ mice by culturing with
M, Schuyler +3 more
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Adoptive Transfer of Immunologically Competent Cells
The Journal of Immunology, 1966Summary Adoptive transfer of a primary agglutinin response to sheep erythrocytes by spleen cells given to cyclophosphamide pretreated mice was studied. Various syngeneic, parent-to-hybrid and allogeneic donor-host combinations were investigated.
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Studying Neutrophil Migration In Vivo Using Adoptive Cell Transfer
2016Adoptive cell transfer experiments can be used to study the roles of cell trafficking molecules on the migratory behavior of specific immune cell populations in vivo. Chemoattractants and their G protein-coupled seven-transmembrane-spanning receptors regulate migration of cells in vivo, and dysregulated expression of chemoattractants and their ...
Yoshishige, Miyabe +3 more
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