Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini +7 more
wiley +1 more source
Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase. [PDF]
Nucleic Acids ResLan M +7 more
europepmc +1 more source
Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
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RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal. [PDF]
EMBO JMiddleton AJ, Day CL.
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A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Uncoupling Protein 1 (UCP1) is a defining feature of brown fat and facilitates the specialized ability of the tissue to generate heat in the process of non‐shivering thermogenesis. The protein is activated by fatty acids, which overcome its inhibition by purine nucleotides, to catalyze proton leak across the mitochondrial inner membrane ...
Riccardo Cavalieri +7 more
wiley +1 more source
Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience. [PDF]
Cancers (Basel)Akkoc Mustafayev FN +10 more
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Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Proposed model for NAD+ metabolism in (A) control and (B) SARM1 activated PBMCs. In native form, 3‐AP and Vacor compete with NAM as an alternative substrate for NAMPT. This consequently decreases generation of NMN and biosynthesis of NAD+ is limited by both a reduction in precursor NMN and direct inhibition of NMNAT by Vacor‐MN and 3‐AP‐MN.
Lila F. Dabill +5 more
wiley +1 more source
Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]
PeerJFan J, Song Y.
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, Volume 20, Issue 5, Page 1284-1298, May 2026.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus. [PDF]
J Biol ChemMa BD, Li JY, Xu JH, Yu T, Kong XD.
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