Results 201 to 210 of about 140,376 (246)

RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal. [PDF]

EMBO J
Middleton AJ, Day CL.
europepmc   +1 more source

Substrate Specificity of B12‐Depedent Ribonucleotide Reductases: Biotechnology and Metabolic Implications

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Ribonucleotide reductases (RNRs) are valuable biocatalysts for the biosynthesis of non‐natural deoxyribonucleotide, relevant in fields like medical science and synthetic biology. In this study, we explore the substrate spectrum of two thermostable RNRs and discuss their implications for nucleotide metabolism and biocatalytical applications ...
Lobna Eltoukhy, Christoph Loderer
wiley   +1 more source

Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience. [PDF]

Cancers (Basel)
Akkoc Mustafayev FN, Fountzilas E, Munsell MF, Layman RM, Yam C, Gutierrez AM, Albarracin CT, Ahmed Z, Schlacher K, Tainer JA, Arun BK.   +10 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]

PeerJ
Fan J, Song Y.
europepmc   +1 more source

ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus. [PDF]

J Biol Chem
Ma BD, Li JY, Xu JH, Yu T, Kong XD.
europepmc   +1 more source

Correction: Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor.

Elife
Liu Q, Xiao Q, Sun Z, Wang B, Wang L, Wang N, Wang K, Song C, Yang Q.   +8 more
europepmc   +1 more source

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells. [PDF]

Transl Oncol
Zhang C, Wang P, Yu J, Yuan J, Zhang L, Li M.   +5 more
europepmc   +1 more source

Real-world data-based assessment of therapy-related myeloid neoplasms after poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Front Oncol
Uekusa R, Yokoi A, Watanabe E, Inoue M, Mizuno K, Yoshida K, Yoshikawa N, Niimi K, Suzuki S, Kajiyama H.   +9 more
europepmc   +1 more source

Recurrent patterns and prognostic factors based on CA-125 and RECIST progression in ovarian cancer patients treated with poly (ADP-ribose) polymerase inhibitors. [PDF]

J Ovarian Res
Zhang B, Lv W, Fu Z, Zhou Y, Du J, Yao Q, Qian Q, Bu H.   +7 more
europepmc   +1 more source