Results 151 to 160 of about 3,533 (177)

GTP stabilization of adenylate cyclase activated and ADP-ribosylated by choleragen

Biochemical and Biophysical Research Communications, 1981
Abstract Choleragen activates adenylate cyclase in human skin fibroblasts by catalyzing the ADP-ribosylation of the 42,000 and 47,000 dalton guanyl nucleotide-binding regulatory components (G) of adenylate cyclase. The ADP-ribose linkage to 42,000 and 47,000 dalton proteins was stable at 30°C for 1 h with or without GTP, whereas GTP was required to ...
S, Nakaya, P A, Watkins, A J, Bitonti, L M, Hjelmeland, J, Moss, M, Vaughan   +5 more
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Purification and Characterization of ADP-Ribosyl Cyclase from Euglena gracilis

Journal of Biochemistry, 1999
ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with
W, Masuda, S, Takenaka, S, Tsuyama, H, Inui, K, Miyatake, Y, Nakano   +5 more
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The expression of messenger RNA for ADP‐ribosyl cyclase in aldosterone‐producing adenomas

Clinical Endocrinology, 2005
SummaryObjective  Cyclic ADP‐ribose (cADPR) has been reported to be as potent and powerful at releasing intracellular Ca2+ as inositol triphosphate (IP3). To determine whether the cADPR system plays a signalling role in angiotensin II (Ang II)‐induced aldosterone synthesis in the human adrenal gland, we investigated the effects of Ang II on ADP‐ribosyl
Yoshiyu, Takeda, Mikiya, Usukura, Takashi, Yoneda, Nobushige, Oda, Yoko, Ito, Hiroshi, Mabuchi   +5 more
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A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

Nature Cell Biology, 1999
Nucleoplasmic calcium ions (Ca2+) influence nuclear functions as critical as gene transcription, apoptosis, DNA repair, topoisomerase activation and polymerase unfolding. Although both inositol trisphosphate receptors and ryanodine receptors, types of Ca2+ channel, are present in the nuclear membrane, their role in the homeostasis of nuclear Ca2 ...
O A, Adebanjo, H K, Anandatheerthavarada, A P, Koval, B S, Moonga, G, Biswas, L, Sun, B R, Sodam, P J, Bevis, C L, Huang, S, Epstein, F A, Lai, N G, Avadhani, M, Zaidi   +12 more
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ADP-ribosylation of brain synaptosomal proteins correlates with adenylate cyclase activation

Biochemical and Biophysical Research Communications, 1982
Abstract ADP-ribosylation of the adenylate cyclase G F regulatory subunit by cholera toxin is a major tool for the study of this enzyme. Investigation of the brain enzyme has been hampered up to now by the failure to demonstrate cholera toxin-dependent ADP-ribosylation of membrane-bound proteins.
G, Berthillier, J, d'Alayer, A, Monneron
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NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

Biochemical and Biophysical Research Communications, 2006
ADP-ribosyl cyclases (ADPRCs) are present from lower Metazoa to mammals and synthesize the Ca2+-active (di)nucleotides cyclic ADP-ribose (cADPR), NAADP+, and ADP-ribose (ADPR), involved in the regulation of important cellular functions. NAADP+ can be synthesized by ADPRCs from NADP+ through a base-exchange reaction, which substitutes nicotinamide for ...
Moreschi, Iliana, Bruzzone, Santina, Melone, Luca, De Flora, Antonio, Zocchi, Elena   +4 more
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Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD+ glycohydrolases

Biochemical Journal, 2000
Highly purified Aplysia californica ADP-ribosyl cyclase was found to be a multifunctional enzyme. In addition to the known transformation of NAD+ into cADP-ribose this enzyme is able to catalyse the solvolysis (hydrolysis and methanolysis) of cADP-ribose.
C, Cakir-Kiefer, H, Muller-Steffner, F, Schuber   +2 more
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Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase

Nature, 1986
Although cholera toxin induces a marked stimulation of adenylate cyclase activity in rat adipocyte plasma membranes, the holotoxin induces only a slight increase of cyclic AMP accumulation in intact cells. A similar apparent anomaly is seen with pertussis toxin, which has been shown to inhibit the Gi subunit of adenylate cyclase, and has a greater ...
C, Jacquemin, H, Thibout, B, Lambert, C, Correze   +3 more
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Altered Regulation of Adenylate Cyclase after Toxin-Catalyzed ADP-Ribosylation

1985
Publisher Summary This chapter presents an analysis of three types of ADP-Ribosylation, namely, ADP-ribosylation of Gs by choleragen, ADP-ribosylation of Gi by pertussis toxin, and ADP-ribosylation of transducin. The other known ADP-ribosyltransferases are bacteriophage products or bacterial toxins whose functions should probably be described as ...
M, Vaughan, J, Moss
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Cyclic ADP-ribose, the ADP-ribosyl cyclase pathway and calcium signalling

Molecular and Cellular Endocrinology, 1994
Cyclic adenosine diphosphate-ribose, an endogenous metabolite of nicotinamide adenine dinucleotide was first characterized as a potent Ca2+ mobilizing agent in sea urchin eggs. Mounting evidence points to it being an endogenous activator of Ca(2+)-induced Ca2+ release by non-skeletal muscle ryanodine receptors in several invertebrate and mammalian cell
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