Results 71 to 80 of about 40,918 (202)

Changes in NAD/ADP-ribose metabolism in rectal cancer

Brazilian Journal of Medical and Biological Research, 2005
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe, L. Turker-Sener, A. Sener, G. Yetkin, D. Tiryaki, E. Bermek   +5 more
doaj   +1 more source

A Highly Conserved SNARE‐Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking

Plant Biotechnology Journal, EarlyView.
ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk, Peitong Li, Hafiz Muhammad Khalid Abbas, Mst Shamira Sultana, Sarbottam Piya, Nicole Coffey, Cengizhan Öztürk, Sobhan Bahrami Zadegan, Susan Thomas Laird, Mazen Alazem, Samantha P. Nuzzi, J. Hollis Rice, Chris Wyman, Tessa Burch‐Smith, Vince Pantalone, Tarek Hewezi   +15 more
wiley   +1 more source

Studying Catabolism of Protein ADP-Ribosylation [PDF]

, 2017
Protein ADP-ribosylation is a conserved posttranslational modification that regulates many major cellular functions, such as DNA repair, transcription, translation, signal transduction, stress response, cell division, aging, and cell death. Protein ADP-ribosyl transferases catalyze the transfer of an ADP-ribose (ADPr) group from the β-nicotinamide ...
Palazzo L., James D. I., Waddell I. D., Ahel I.   +3 more
openaire   +5 more sources

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, Volume 125, Issue 2, Page 145-158, February 2026.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

Molecular mechanisms of plant NLR activation and signalling

The Plant Journal, Volume 125, Issue 3, February 2026.
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta, Mitchell Sorbello, Laura Garzon‐Flores, Bostjan Kobe   +3 more
wiley   +1 more source

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

The EMBO Journal
Protein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Victoria Chaves Ribeiro, Lilian Cristina Russo, Nícolas Carlos Hoch   +2 more
doaj   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct
One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
doaj   +1 more source

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source

The PARP1/ARTD1-Mediated Poly-ADP-Ribosylation and DNA Damage Repair in B Cell Diversification

Antibodies, 2014
ADP-ribosylation is an essential post-translational modification, mediated by a family of proteins named poly-ADP-ribose polymerases/Diphtheria toxin-like ADP-ribosyltransferases (PARPs/ARTDs), that functions to assist in cellular homeostasis through an ...
Jackline J.M. Lasola, Andrea Hodgson, Xin Sun, Fengyi Wan   +3 more
doaj   +1 more source