Results 1 to 10 of about 45,797 (235)

Class I ADP-ribosylation factors are involved in enterovirus 71 replication. [PDF]

PLoS ONE, 2014
Enterovirus 71 is one of the major causative agents of hand, foot, and mouth disease in infants and children. Replication of enterovirus 71 depends on host cellular factors.
Jianmin Wang, Jiang Du, Qi Jin
doaj   +2 more sources

Genome-wide identification and expression analysis of ADP-ribosylation factors associated with biotic and abiotic stress in wheat (Triticum aestivum L.) [PDF]

PeerJ, 2021
The ARF gene family plays important roles in intracellular transport in eukaryotes and is involved in conferring tolerance to biotic and abiotic stresses in plants. To explore the role of these genes in the development of wheat (Triticum aestivum L.), 74
Yaqian Li, Jinghan Song, Guang Zhu, Zehao Hou, Lin Wang, Xiaoxue Wu, Zhengwu Fang, Yike Liu, Chunbao Gao   +8 more
doaj   +3 more sources

PARP10 is critical for stress granule initiation [PDF]

Life Science Alliance
This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment. Stress granules (SGs) are cytoplasmic biomolecular condensates enriched with RNA
Aravinth Kumar Jayabalan, Krishna Bhambhani, Anthony KL Leung   +2 more
doaj   +2 more sources

Cathepsin E drives colorectal cancer progression and immune evasion via ZNF326 ADP-ribosylation and TGF-β/SMAD activation [PDF]

Journal of Translational Medicine
Background Colorectal cancer (CRC) is a leading malignant tumor worldwide with rising morbidity and mortality. Cathepsin E (CTSE), a member of the cysteinyl asparaginase family, is implicated in immune responses, antigen processing, and cellular ...
Huan Zhang, Jie Feng, Mengxin Zhu, Tongguo Shi, Qinhua Xi   +4 more
doaj   +2 more sources

PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140 [PDF]

Molecular Medicine
Background Acute lung injury (ALI) carries significant mortality with limited targeted therapies. Macrophages drive early inflammatory propagation in ALI, exacerbating pulmonary inflammation.
Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang, Yanmei Zhang   +8 more
doaj   +2 more sources

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling

Nature Communications, 2023
In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors.
Pietro Fontana, Sara C. Buch-Larsen, Osamu Suyari, Rebecca Smith, Marcin J. Suskiewicz, Kira Schützenhofer, Antonio Ariza, Johannes Gregor Matthias Rack, Michael L. Nielsen, Ivan Ahel   +9 more
doaj   +1 more source

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Toxins, 2021
One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines.
Marieke Esther Hoonakker
doaj   +1 more source

Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts. [PDF]

PLoS Genetics, 2014
Post-translational protein modifications such as phosphorylation and ubiquitinylation are common molecular targets of conflict between viruses and their hosts. However, the role of other post-translational modifications, such as ADP-ribosylation, in host-
Matthew D Daugherty, Janet M Young, Julie A Kerns, Harmit S Malik   +3 more
doaj   +1 more source

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion

Molecular & Cellular Oncology, 2020
Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation
Kossay Zaoui, Harvey Wilmore Smith, Morag Park, Stéphanie Duhamel   +3 more
doaj   +1 more source