Results 11 to 20 of about 7,446,455 (132)
ADP-ribosylation from molecular mechanisms to therapeutic implications. [PDF]
, 2023 ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.
I Ahel (7716542) +3 more
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TARG1 protects against toxic DNA ADP-ribosylation [PDF]
, 2021 ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases.
Sanchi, Andrea +7 more
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BIOCHEMICAL AND STRUCTURAL STUDIES OF PATHOGEN EFFECTORS ASSOCIATED WITH UBIQUITIN ADP-RIBOSYLATION
, 2023 Ubiquitination and ADP-ribosylation are reversible post-translational modifications involved in various cellular activities. Pathogens like Legionella pneumophila and Chromobacterium violaceum target host ubiquitin system via modifications involving ADP ...
Zhengrui Zhang (17081689)
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, 2019 ADP-ribosylation is a post-translational modification that, until recently, has remained elusive to study at the cellular level. Previously dependent on radioactive tracers to identify ADP-ribosylation targets, several advances in mass spectrometric ...
Takashi Maejima (559317) +6 more
core +3 more sources
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Molecular Cancer, 2020 Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian
He Li +5 more
doaj +1 more source
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Frontiers in Microbiology, 2021 Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B.
Florian Stieglitz +4 more
doaj +1 more source
, 2022 Recently developed chemical and enzyme-based technologies to install serine ADP-ribosylation onto synthetic peptides have enabled new approaches to study poly(ADP-ribose) polymerase (PARP) biology.
Chad A. Brautigam (242609) +7 more
core +1 more source
In Vivo Level of Poly(ADP-ribose)
Challenges, 2018 PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synthesis
Masanao Miwa +9 more
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Toxins, 2020 Pathogenic microorganisms produce various virulence factors, e.g., enzymes, cytotoxins, effectors, which trigger development of pathologies in infectious diseases. Cholera toxin (CT) produced by O1 and O139 serotypes of Vibrio cholerae (V. cholerae) is a
Kohei Ogura, Kinnosuke Yahiro, Joel Moss
doaj +1 more source
Key molecules of Mucorales for COVID-19-associated mucormycosis: a narrative review
Journal of Bio-X Research, 2022 Mucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales.
Priyanka Baberwal +3 more
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