Results 21 to 30 of about 45,797 (235)
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Molecular Cancer, 2020 Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian
He Li +5 more
doaj +1 more source
The potential role and application of PARP inhibitors in cancer treatment [PDF]
, 2009 Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core +2 more sources
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Frontiers in Microbiology, 2021 Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B.
Florian Stieglitz +4 more
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Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
Regulation of Transcription Factor NFAT by ADP-Ribosylation [PDF]
Molecular and Cellular Biology, 2008 ADP-ribosylation is a reversible posttranslational modification mediated by poly-ADP-ribose polymerase (PARP). The results of recent studies demonstrate that ADP-ribosylation contributes to transcription regulation. Here, we report that transcription factor NFAT binds to and is ADP-ribosylated by PARP-1 in an activation-dependent manner ...
Opeyemi A, Olabisi +8 more
openaire +2 more sources
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source
In Vivo Level of Poly(ADP-ribose)
Challenges, 2018 PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synthesis
Masanao Miwa +9 more
doaj +1 more source
Toxins, 2020 Pathogenic microorganisms produce various virulence factors, e.g., enzymes, cytotoxins, effectors, which trigger development of pathologies in infectious diseases. Cholera toxin (CT) produced by O1 and O139 serotypes of Vibrio cholerae (V. cholerae) is a
Kohei Ogura, Kinnosuke Yahiro, Joel Moss
doaj +1 more source
Key molecules of Mucorales for COVID-19-associated mucormycosis: a narrative review
Journal of Bio-X Research, 2022 Mucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales.
Priyanka Baberwal +3 more
doaj +1 more source
ADP‐ribosylated elongation factor 2 (ADP‐ribosyl‐EF‐2) is unable to promote translocation within the ribosome [PDF]
FEBS Letters, 1990 Elongation factor 2 (EF‐2), ADP‐ribosylated in vitro by the A‐fragment of diphtheria toxin, can (in the presence of GMPPCP) form stable corn plexes with ribosomes regardless of whether the ribosomes are empty or carrying poly(U) and Phe‐tRNA in the A‐site.
Davydova, E.K., Ovchinnikov, L.P.
openaire +2 more sources