Results 51 to 60 of about 45,518 (211)

CARF regulates the alternative splicing and piwi/piRNA complexes during mouse spermatogenesis through PABPC1

Acta Biochimica et Biophysica Sinica
ADP-ribosylation factor collaborator (CARF), which is also known as CDKN2AIP, was first recognized as an ADP-ribosylation factor-interacting protein that participates in the activation of the ARF-p53-p21 (WAF1 ...
Cao Yuming, Wang Shengnan, Liu Jie, Xu Jinfeng, Liang Yan, Ao Fei, Wei Zexiao, Wang Li   +7 more
doaj   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Transcriptomic Reprogramming, Alternative Splicing and RNA Methylation in Potato (Solanum tuberosum L.) Plants in Response to Potato Virus Y Infection

Plants, 2022
Plant-virus interactions are greatly influenced by environmental factors such as temperatures. In virus-infected plants, enhanced temperature is frequently associated with more severe symptoms and higher virus content. However, the mechanisms involved in
Anna Glushkevich, Nadezhda Spechenkova, Igor Fesenko, Andrey Knyazev, Viktoriya Samarskaya, Natalia O. Kalinina, Michael Taliansky, Andrew J. Love   +7 more
doaj   +1 more source

Class II ADP-ribosylation factors are required for efficient secretion of Dengue viruses [PDF]

, 2011
This article is available open access through the publisher’s website.Identification and characterization of virus-host interactions are very important steps toward a better understanding of the molecular mechanisms responsible for disease progression ...
Brault, JB, Bruzzone, R, Despre, P, Kudelko, M, Kwok, K, Li, MY, Nal, B, Pardigon, N, Peiris, JSM, Wang, PG   +9 more
core   +3 more sources

Transcriptional regulation mechanism of PARP1 and its application in disease treatment

Epigenetics & Chromatin
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear enzyme is also involved in transcriptional regulation.
Yu Lu, Wenliang Fu, Weiwei Xing, Haowei Wu, Chao Zhang, Donggang Xu   +5 more
doaj   +1 more source

Critical assessment of microscopy methods for detecting single- and double-strand DNA breaks

Folia Histochemica et Cytobiologica
A laboratory toolbox for detecting and quantifying DNA breaks in animal cells and tissues includes various methods that employ biochemical tests, DNA sequencing, or imaging approaches.
Agnieszka Hoang-Bujnowicz, Julita Wesolowska, Agnieszka Ostromecka, Beata Nosal, Weronika Pawlus, Svitlana Levchenko, Miroslaw Zarebski, Jurek W. Dobrucki   +7 more
doaj   +1 more source

Clinical implication and immunological characterisation of the ARF-GEF family member CYTH4 in ovarian cancer

Autoimmunity, 2020
Background The GTP exchange factors on ADP-ribosylation factor (ARF) mediate the GDP/GTP exchange on ARF, serve as regulators in protein trafficking and membrane dynamics, and play critical roles in various cell processes.
Qinyi Zhang, Qingying Wang, Sufang Wu, Jiawen Zhang   +3 more
doaj   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Clostridial binary toxins: iota and C2 family portraits

Frontiers in Cellular and Infection Microbiology, 2011
There are many pathogenic Clostridium species with diverse virulence factors that include protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens and C. spiroforme, cause enteric problems in animals as well as humans.
Bradley G. Stiles, Darran J. Wigelsworth, Michel R. Popoff, Holger eBarth   +3 more
doaj   +1 more source