Results 151 to 160 of about 7,274 (190)
, 1989 Polymerization of ADP-ribose from NAD+ by poly(ADP-ribose) transferase is initiated by auto-mono-ADP-ribosylation of the enzyme followed by ADP-ribose transfer to other acceptor proteins and subsequent elongation (1). DNA is required as a coenzyme, and an enzyme-associated DNA, defined as sDNA (2), can be isolated which is more efficient than crude ...
Alaeddin Hakam +3 more
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Molecular Carcinogenesis, 1999 The aim of this work was to study the role of the tumor suppressor p53 and of poly(ADP-ribose) transferase (pADPRT) in the control of hepatocyte apoptosis in two different in vivo models, i.e., during the process of tumor initiation by the genotoxin and cytotoxin N-nitrosomorpholine (NNM) and after withdrawal of the hepatomitogen cyproterone acetate ...
Józefa We ̧sierska‐Ga ̧dek +3 more
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Biochemical and Biophysical Research Communications, 1984 Rats fed a synthetic diet containing 0.25% benzamide, 0.1% phenobarbital, separately or in combination, for two weeks showed a significant augmentation in the activity of nuclear poly(ADP-ribose) polymerase as well as changes in various nuclear, microsomal and cytosolic liver enzymes involved in the metabolism of xenobiotics.
Martin J. Griffin +5 more
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International Journal of Radiation Oncology*Biology*Physics, 1988 Four newly-established human tumor cell lines, have been irradiated at dose rates of 150 and 3.2 cGy/min to compare their capacity to repair radiation damage. They included a neuroblastoma, a germ-cell carcinoma of the testis, a large cell carcinoma of the lung, and a carcinoma of the cervix. The four lines varied in their sensitivity to high dose-rate
Lloyd R. Kèlland +2 more
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, 1989 Investigation of the cellular role of the nuclear protein modification ADP-ribosylation has depended heavily on the use of benzamides as inhibitors of ADP-ribosyl transferase (EC 2.4.2.30) in intact cell studies. The substituted benzamides were first introduced by Whish (1) and have proved to be useful inhibitors of low toxicity and fairly high ...
C. J. Skidmore +2 more
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, 1989 The molecular mechanism of poly(ADP-ribose) transferase activation following the treatment of mammalian cells with DNA damaging agents is still unknown. Several lines of evidence indicate that the activation process does not require de novo synthesis of the enzyme and that the extent of increase in activity is correlated to the type of DNA damage (1 ...
A. Ivana Scovassi +4 more
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Mutagenesis, 1990 The effect on somatic mutations and recombination by 3-aminobenzamide (3-ABA), an inhibitor of poly(ADP-ribose) transferase, was studied in the somatic wing spot test in Drosophila melanogaster, 3-ABA did not exert any effect by itself, but caused a strong increase of wing spots in combination with methyl methanesulphonate (MMS) and ethylnitrosourea ...
Jan Magnusson, Claes Ramel
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Loss of Poly(ADP-Ribose) Transferase Activity in Liver of Rats Treated with 2-Acetylaminofluorene
, 1989 The chronic exposure of rats to a feeding regimen containing subcarcinogenic doses of N-2-acetylaminofluorene (2AAF) induces, in liver, multiple effects and the progression to hepatocellular carcinoma(s) (1). Among the effects induced at the hepatocellular level, which seem to play a crucial role in the initial steps of the carcinogenic process, are ...
C. F. Cesarone +5 more
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, 1992 Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other ...
Nadia Raffaelli +6 more
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Analogues of benzamide containing a sulfur atom as poly(ADP-ribose) transferase inhibitors.
Biochemistry international, 1987 Structural analogues of benzamide (BA) containing a sulfur atom were tested for their ability to inhibit the enzyme poly(ADP-ribose)transferase (ADPRT) in cultured Chinese Hamster Ovary (CHO) cells. These compounds were benzene sulfonamide (BSA), thiobenzamide (TB) and 3-thiophene carboxamide (TCA) and their activity was compared with that of benzamide
Orazio Cantoni +5 more
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