Results 31 to 40 of about 199,574 (231)
Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2. [PDF]
PLoS ONE, 2010 Retroviral insertional mutagenesis provides an effective forward genetic method for identifying genes involved in essential cellular pathways. A Chinese hamster ovary cell line mutant resistant to several bacterial ADP-ribosylating was obtained by this ...
Pradeep K Gupta +2 more
doaj +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
ADP-Ribosylation and Antiviral Resistance in Plants
Viruses, 2023 ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova +4 more
doaj +1 more source
Toxins, 2015 Pathogenesis of cholera diarrhea requires cholera toxin (CT)-mediated adenosine diphosphate (ADP)-ribosylation of stimulatory G protein (Gsα) in enterocytes. CT is an AB5 toxin with an inactive CTA1 domain linked via CTA2 to a pentameric receptor-binding
Michael G. Jobling +3 more
doaj +1 more source
C9orf72 Toxic Species Affect ArfGAP-1 Function
Cells, 2023 Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi +9 more
doaj +1 more source
An Enhanced Approximate Dynamic Programming Approach to On-demand Ride Pooling [PDF]
arXiv, 2023 Ride-pooling services have been growing in popularity, increasing the need for efficient and effective operations. The main goal of ride-pooling services is to maximize the number of passengers served while minimizing wait and delay times. However, factors such as the timing and volume of passenger requests, pick-up and drop-off locations, available ...
arxiv
Pion Form Factors at Intermediate Momentum Transfer in a Covariant Approach [PDF]
Int.J.Mod.Phys.A11:655-676,1996, 1993 We study the pion electromagnetic and $\gamma^* + \pi^0 \to \gamma$ transition form factors at intermediate momentum transfer. We calculate soft, nonperturbative corrections to the leading perturbative amplitudes which arise from the $q\bar q$-component of the pion wave function.
arxiv +1 more source
PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]
, 2010 PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel +59 more
core +1 more source
mBio, 2016 ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets.
Anthony R. Fehr +8 more
doaj +1 more source