Results 41 to 50 of about 21,073 (261)
β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis [PDF]
Journal of Biological Chemistry, 2001 β-Arrestins are multifunctional adaptor proteins known to regulate internalization of agonist-stimulated G protein-coupled receptors by linking them to endocytic proteins such as clathrin and AP-2. Here we describe a previously unappreciated mechanism by
Audrey Claing +6 more
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Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1
OncoTarget, 2016 Metastasis is the major cause of cancer-related death in breast cancer patients, which is controlled by specific sets of genes. Targeting these genes may provide a means to delay cancer progression and allow local treatment to be more effective.
Xiayang Xie +7 more
semanticscholar +1 more source
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
Journal of the American Society of Nephrology, 2016 The gene for ADP ribosylation factor-like GTPase 13B (Arl13b) encodes a small GTPase essential for cilia biogenesis in multiple model organisms. Inactivation of arl13b in zebrafish leads to a number of phenotypes indicative of defective cilia, including ...
Yuanyuan Li +6 more
semanticscholar +1 more source
eNeuro, 2016 During neural development, endosomal trafficking controls cell shape and motility through the polarized transport of membrane proteins related to cell–cell and cell–extracellular matrix interactions.
Y. Hara +5 more
semanticscholar +1 more source
Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2. [PDF]
PLoS ONE, 2010 Retroviral insertional mutagenesis provides an effective forward genetic method for identifying genes involved in essential cellular pathways. A Chinese hamster ovary cell line mutant resistant to several bacterial ADP-ribosylating was obtained by this ...
Pradeep K Gupta +2 more
doaj +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
Localization and function of ADP ribosylation factor A in Aspergillus nidulans [PDF]
FEMS Microbiology Letters, 2008 Filamentous fungi undergo polarized hyphal growth throughout the majority of their life cycle. The Spitzenkörper is a structure unique to filamentous fungi that participates in hyphal growth and is composed largely of vesicles. An important class of proteins involved in vesicle assembly and trafficking are the ADP-ribosylation factors (Arfs).
Soo Chan Lee +2 more
openaire +3 more sources
Journal of Cell Biology, 1999 Expression cloning from a cDNA library prepared from a mutant CHO cell line with Golgi-specific resistance to Brefeldin A (BFA) identified a novel 206-kD protein with a Sec7 domain termed GBF1 for Golgi BFA resistance factor 1.
A. Claude +8 more
semanticscholar +1 more source
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis.
PLoS ONE, 2023 Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is ...
Venkateswara R Gogulamudi +9 more
doaj +1 more source
A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]
, 2017 Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David +12 more
core +2 more sources