Results 41 to 50 of about 77,829 (292)

A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

Toxins, 2015
Pathogenesis of cholera diarrhea requires cholera toxin (CT)-mediated adenosine diphosphate (ADP)-ribosylation of stimulatory G protein (Gsα) in enterocytes. CT is an AB5 toxin with an inactive CTA1 domain linked via CTA2 to a pentameric receptor-binding
Michael G. Jobling, Lisa F. Gotow, Zhijie Yang, Randall K. Holmes   +3 more
doaj   +1 more source

Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2. [PDF]

PLoS ONE, 2010
Retroviral insertional mutagenesis provides an effective forward genetic method for identifying genes involved in essential cellular pathways. A Chinese hamster ovary cell line mutant resistant to several bacterial ADP-ribosylating was obtained by this ...
Pradeep K Gupta, Shihui Liu, Stephen H Leppla   +2 more
doaj   +1 more source

ADP‐ribosylated elongation factor 2 (ADP‐ribosyl‐EF‐2) is unable to promote translocation within the ribosome [PDF]

FEBS Letters, 1990
Elongation factor 2 (EF‐2), ADP‐ribosylated in vitro by the A‐fragment of diphtheria toxin, can (in the presence of GMPPCP) form stable corn plexes with ribosomes regardless of whether the ribosomes are empty or carrying poly(U) and Phe‐tRNA in the A‐site.
Davydova, E.K., Ovchinnikov, L.P.
openaire   +2 more sources

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

mBio, 2016
ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets.
Anthony R. Fehr, Rudragouda Channappanavar, Gytis Jankevicius, Craig Fett, Jincun Zhao, Jeremiah Athmer, David K. Meyerholz, Ivan Ahel, Stanley Perlman   +8 more
doaj   +1 more source

ADP-Ribosylation and Antiviral Resistance in Plants

Viruses, 2023
ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova, Natalya O. Kalinina, Sergey K. Zavriev, Andrew J. Love, Michael Taliansky   +4 more
doaj   +1 more source

ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin

eNeuro, 2016
During neural development, endosomal trafficking controls cell shape and motility through the polarized transport of membrane proteins related to cell–cell and cell–extracellular matrix interactions.
Y. Hara, M. Fukaya, K. Hayashi, T. Kawauchi, K. Nakajima, H. Sakagami   +5 more
semanticscholar   +1 more source

C9orf72 Toxic Species Affect ArfGAP-1 Function

Cells, 2023
Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra   +9 more
doaj   +1 more source

ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes

Journal of Cell Biology, 1998
Small GTP-binding proteins such as ADP- ribosylation factor 1 (ARF1) and Sar1p regulate the membrane association of coat proteins involved in intracellular membrane trafficking.
C. E. Ooi, E. C. Dell’Angelica, J. Bonifacino   +2 more
semanticscholar   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Adp Ribosylation Factor-like Protein 2 (Arl2) Regulates the Interaction of Tubulin-Folding Cofactor D with Native Tubulin

Journal of Cell Biology, 2000
The ADP ribosylation factor-like proteins (Arls) are a family of small monomeric G proteins of unknown function. Here, we show that Arl2 interacts with the tubulin-specific chaperone protein known as cofactor D.
Arunashree Bhamidipati, S. Lewis, N. Cowan   +2 more
semanticscholar   +1 more source