Results 71 to 80 of about 77,829 (292)

Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis

Cells, 2022
In phagocytes, cytoskeletal and membrane remodeling is finely regulated at the phagocytic cup. Various smaFll G proteins, including those of the Arf family, control these dynamic processes.
François C. Chouinard, Lynn Davis, Caroline Gilbert, Sylvain G. Bourgoin   +3 more
doaj   +1 more source

Structure ofPlasmodium falciparumADP-ribosylation factor 1 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2010
Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and ...
William J, Cook, Craig D, Smith, Olga, Senkovich, Anthony A, Holder, Debasish, Chattopadhyay   +4 more
openaire   +2 more sources

The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]

, 2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika, Nikiforov, Andrey, Ziegler, Mathias   +2 more
core   +2 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.

PLoS ONE, 2018
Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells.
Kizuku Watanabe, Jiro Kato, Jianfeng Zhu, Hirotake Oda, Hiroko Ishiwata-Endo, Joel Moss   +5 more
doaj   +1 more source

ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity*

Journal of Biological Chemistry, 2015
Background: Conflicting results regarding the role of ARF6 in dendritic spine development have not been answered. Results: ARF6-mediated Rac1 or RhoA activation via PLD pathway either positively or negatively regulates spine formation.
Yoonju Kim, Sang-Eun Lee, Joohyun Park, Minhyung Kim, Boyoon Lee, D. Hwang, Sunghoe Chang   +6 more
semanticscholar   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation [PDF]

, 2009
Poly(ADP-ribosyl)ation of the conserved multifunctional transcription factor CTCF was previously identified as important to maintain CTCF insulator and chromatin barrier functions.
Chernukhin, Igor, Farrar, Dawn, Ito, Yoko, Jagodic, Maja, Klenova, Elena, Murrell, Adele, Ohlsson, Rolf, Rai, Sushma, Yammine, Samer   +8 more
core   +2 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source