Results 61 to 70 of about 16,655 (259)

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation [PDF]

, 2015
Purpose Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life.
Bacallao, Robert L., Bahler, Clinton D., Shumate, Ashley M., Sundaram, Chandru P., Tellman, Matthew W.   +4 more
core   +1 more source

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tract [PDF]

, 2019
Background: Mutations in hepatocyte nuclear factor 1B (HNF1B) have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in humans. Diabetes and other less frequent anomalies have also been described.
Aguayo Calcena, Aníbal, Ariceta, Gema, Castaño González, Luis Antonio, García Castaño, Alejandro, Madariaga Domínguez, Leire, Martínez Salazar, Rosa   +5 more
core   +2 more sources

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, Volume 182, Issue 19, Page 4611-4624, October 2025.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

Risk of Hospital Encounters With Kidney Stones in Autosomal Dominant Polycystic Kidney Disease: A Cohort Study

Canadian Journal of Kidney Health and Disease, 2021
Background: There is a perception that patients with autosomal dominant polycystic kidney disease (ADPKD) are more likely to develop kidney stones than the general population.
Vinusha Kalatharan, Blayne Welk, Danielle M. Nash, Stephanie N. Dixon, Justin Slater, York Pei, Sisira Sarma, Amit X. Garg   +7 more
doaj   +1 more source

Extrarenal manifestations of ADPKD

Kidney International, 1997
A 47-year-old woman was evaluated in the Nephrology Clinic at New England Medical Center for autosomal dominant polycystic kidney disease (ADPKD). She had undergone abdominal and pelvic noncontrast computed tomographic scans for the evaluation of dyspareunia and stress incontinence.
openaire   +2 more sources

A clinician's guide to the diagnosis and management of kidney cysts

Internal Medicine Journal, Volume 55, Issue 10, Page 1752-1756, October 2025.
Abstract Kidney cysts are frequently encountered as incidental findings on imaging studies and are typically benign in nature. However, certain cysts exhibit characteristics that may predispose them to malignant transformation. The Bosniak classification, based on contrast‐enhanced computed tomography or magnetic resonance imaging, offers a systematic ...
Kate Brotherton, Bobby Chacko
wiley   +1 more source

Building a network of ADPKD reference centres across Europe: the EuroCYST initiative [PDF]

, 2016
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic inherited kidney disease, affecting an estimated 600 000 individuals in Europe. The disease is characterized by age-dependent development of a multiple cysts in
Budde, Klemens, Chaveau, Dominique, Devuyst, Olivier, Ecder, Tevfik, Eckardt, Kai-Uwe, Gansevoort, Ron T., Köttgen, Anna, Le Meur, Yannick, Ong, Albert C M., Petzold, Katja, Pirson, Yves, Remuzzi, Giuseppe, Rotar, Laura, Sandford, Richard, Serra, Andreas L., Tesar, Vladimir, Torra, Roser, Wüthrich, Rudolf P.   +17 more
core   +2 more sources

Burden of Valvular Heart Disease Diagnosed on Protocolised Echocardiography for Waitlist Placement in End‐Stage Kidney Patients

Nephrology, Volume 30, Issue 10, October 2025.
This retrospective cohort study investigates the epidemiology, impact on survival, and risk factors for valvular heart disease in a multi‐ethnic Asian population referred to the kidney transplant waitlist. ABSTRACT Aim The burden of valvular heart disease (VHD), which is high amongst end‐stage kidney disease patients (ESKD), is less well defined in ...
Quan Yao Ho, Ningyan Wong, Ian Tatt Liew, Carolyn Shan‐Yeu Tien, Yan Nerng Lye, Haoyang Chen, Sharel Zi Hui Ong, Jia Qin Tan, Chin Yee Lee, Sobhana Thangaraju, Yann Shan Keh, Khung Keong Yeo, Terrance Siang Jin Chua, Terence Kee   +13 more
wiley   +1 more source