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New England Journal of Medicine, 2019 Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients.
Falhammar, Henrik +2 more
core +7 more sources
Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
AIP Conference Proceedings 1798, 020111, 2017, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
Kaslik, Eva +2 more
arxiv +3 more sources
Pituitary-Adrenal Axis in Prader Willi Syndrome [PDF]
Diseases, 2016 Purpose: Prader Willi syndrome (PWS) is a rare genetic condition that has concurrent endocrinological insufficiencies. The presence of growth hormone deficiency has been well documented, but adrenal insufficiency (AI) is not widely reported. A review was
Olivia S. Edgar +2 more
doaj +4 more sources
Endocrine Connections, 2023 We applied 24-h Holter monitoring to analyze the characteristics of arrhythmias and heart rate variability in Chinese patients with primary aldosteronism (PA) and compared them with age-, sex-, and blood pressure-matched primary hypertension (PH ...
Shuang Wan +6 more
doaj +1 more source
A Novel Diagnostic Model for Primary Adrenal Lymphoma
Frontiers in Endocrinology, 2021 ObjectivePrimary adrenal lymphoma (PAL) is easily misdiagnosed as other adrenal masses, such as adrenocortical carcinoma and pheochromocytoma, but patients with PAL benefit little from surgery. The diagnostic method for PAL thus far is limited to adrenal
Kai Yu +7 more
doaj +1 more source
Adrenal crisis and mortality rate in adrenal insufficiency and congenital adrenal hyperplasia [PDF]
Archives of Endocrinology and Metabolism, 2021 Primary adrenal insufficiency (PAI) is characterized by the inability of the adrenal cortex to produce sufficient amounts of glucocorticoids and/or mineralocorticoids. Addison's disease (AD) and congenital adrenal hyperplasia (CAH) are the most frequent disorders in adults and children, respectively. Despite the diagnostic advances and the availability
Lia Mesquita Lousada +2 more
openaire +7 more sources
BMC Endocrine Disorders, 2023 Background Primary bilateral macronodular adrenal hyperplasia (PMAH) combined with infection by an opportunistic pathogen is complicated. Clinical evidence on managing PMAH patients with infections by opportunistic pathogens is insufficient.
Lu Tan +5 more
doaj +1 more source
eLife, 2023 Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa for assisted reproductive technology.
Laura Moutard +14 more
doaj +1 more source
Developing a research database of primary aldosteronism: rationale and baseline characteristics
BMC Endocrine Disorders, 2021 Background Management of primary aldosteronism (PA) has become a research hotspot in the field of endocrinology. To obtain reliable research evidence, it is necessary to establish a high-quality PA research database.
Wen Wang +8 more
doaj +1 more source
Frontiers in Endocrinology, 2021 ObjectivesThe main cardiac features of primary aldosteronism (PA) are impaired left ventricular (LV) diastolic function, and some articles also reported more cardiac fibrosis in PA patients.
Fangli Zhou +8 more
doaj +1 more source