Results 91 to 100 of about 577,986 (368)

Epileptiform Activity and Seizure Risk Follow Long‐Term Non‐Linear Attractor Dynamics

Advanced Science, EarlyView.
This study leverages the HAVOK framework to model long‐term, nonlinear attractor dynamics underlying epileptiform activity and seizure risk in epilepsy patients. By identifying key forcing mechanisms driving chaotic transitions, the findings improve seizure risk forecasting over multi‐day cycles and provide a pathway for personalized, data‐driven ...
Richard E Rosch, Brittany Scheid, Kathryn A Davis, Brian Litt, Arian Ashourvan   +4 more
wiley   +1 more source

Clinical case seminar - Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita [PDF]

, 2002
Mutations in the orphan nuclear receptor DAX-1 cause X-linked adrenal hypoplasia congenita. Affected boys usually present with primary adrenal failure in early infancy or childhood.
Achermann, JC, Beck-Peccoz, P, Borretta, G, Jameson, JL, Mantovani, G, Ozisik, G, Persani, L, Romoli, R, Spada, A   +8 more
core  

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Adropin Stimulates Proliferation and Inhibits Adrenocortical Steroidogenesis in the Human Adrenal Carcinoma (HAC15) Cell Line

Frontiers in Endocrinology, 2020
Adropin is a multifunctional peptide hormone encoded by the ENHO (energy homeostasis associated) gene. It plays a role in mechanisms related to increased adiposity, insulin resistance, as well as glucose, and lipid metabolism.
Ewelina Stelcer, Ewelina Stelcer, Ewelina Stelcer, Paulina Milecka, Hanna Komarowska, Karol Jopek, Marianna Tyczewska, Marta Szyszka, Marta Lesniczak, Wiktoria Suchorska, Wiktoria Suchorska, Karlygash Bekova, Beata Szczepaniak, Marek Ruchala, Marek Karczewski, Tomasz Wierzbicki, Witold Szaflarski, Ludwik K. Malendowicz, Marcin Rucinski   +18 more
doaj   +1 more source

A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]

arXiv, 2022
This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv  

Laparoscopic partial adrenalectomy for bilateral pheochromocytomas in a boy with von Hippel-Lindau disease [PDF]

, 2000
Objectives: In adults, increasing numbers of adrenalectomies for pheochromocytomas are performed laparoscopically. We report for the first time laparoscopic bilateral subtotal adrenalectomy for pheochromocytomas in an 8-year-old boy with von Hippel ...
Bartsch, Georg, Elsner, Romy, Janetschek, Günter, Neumann, Hartmut, Radmayr, Christian   +4 more
core   +1 more source

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors

Brazilian Journal of Medical and Biological Research, 2001
In addition to the mutations that underlie most cases of the multiple endocrine neoplasia type 1 (MEN1) syndrome, somatic mutations of the MEN1 gene have also been described in sporadic tumors like gastrinomas, insulinomas and bronchial carcinoid ...
S.C. Costa, L.S. Nascimento, F.J. Ferreira, P.S. Mattos, L.H. Camara-Lopes, L.S. Ward   +5 more
doaj   +1 more source