Results 111 to 120 of about 532,082 (343)
The role of mTOR pathway as target for treatment in adrenocortical cancer
Endocrine Connections, 2019 Adrenocortical carcinomas (ACCs) are rare tumors with scant treatment options for which new treatments are required. The mTOR pathway mediates the intracellular signals of several growth factors, including the insulin-like growth factors (IGFs), and ...
Maria Cristina De Martino +7 more
doaj +1 more source
European Journal of Endocrinology, 2016 OBJECTIVE To perform a systematic review of published literature on adrenal biopsy and to assess its performance in diagnosing adrenal malignancy.
I. Bancos +7 more
semanticscholar +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Despite availability of biologics and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit +13 more
wiley +1 more source
Scientific Reports, 2015 To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we analyzed samples of human serum and epidermis and pig adrenals for the ...
A. Slominski +6 more
semanticscholar +1 more source
Expert Perspective: Diagnosis and Treatment of Castleman Disease
Arthritis &Rheumatology, Accepted Article.Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen +2 more
wiley +1 more source
Extensive expertise in endocrinology. Adrenal crisis.
European Journal of Endocrinology, 2015 Adrenal crisis is a life-threatening emergency contributing to the excess mortality of patients with adrenal insufficiency. Studies in patients on chronic replacement therapy for adrenal insufficiency have revealed an incidence of 5-10 adrenal crises/100
B. Allolio
semanticscholar +1 more source
STUDIES IN CUSHING'S SYNDROME. III. URINARY 17-KETOSTEROIDS IN PATIENTS WITH BILATERAL ADRENAL CORTICAL HYPERPLASIA* [PDF]
, 1959 Joseph W. Jailer +3 more
openalex +1 more source
Endocrine Connections, 2016 Primary adrenal insufficiency is caused by loss of function of the adrenal gland itself, for example due to autoimmune-mediated destruction of adrenocortical tissue or surgical removal of the adrenal glands or due to inborn disruption of adrenal cortisol
W. Arlt
semanticscholar +1 more source
Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk +3 more
wiley +1 more source