Results 81 to 90 of about 532,082 (343)
Advanced Science, EarlyView.Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim +9 more
wiley +1 more source
Minimal Effects of Rearing Enrichments on Pullet Behaviour and Welfare
Animals, 2020 In Australia, free-range pullets are typically reared indoors, which may hinder later adjustment to outdoor access. Rearing enrichments could optimise pullet development.
Dana L.M. Campbell +3 more
doaj +1 more source
Journal of Clinical Endocrinology and Metabolism, 2016 CONTEXT The diagnosis of adrenal insufficiency is clinically challenging and often requires ACTH stimulation tests. OBJECTIVE To determine the diagnostic accuracy of the high- (250 mcg) and low- (1 mcg) dose ACTH stimulation tests in the diagnosis of ...
N. Ospina +8 more
semanticscholar +1 more source
Advances in Medical Devices for Augmented Acupuncture Therapy
Advanced Science, EarlyView.Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai +7 more
wiley +1 more source
Advanced Science, EarlyView.Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter +29 more
wiley +2 more sources
Advanced Science, EarlyView.This study demonstrates a pump‐free, hydraulic‐amplification oscillatory microfluidic device, which generates oscillatory flows by deforming flexible microchannels through reciprocating finger pressing. The mechanism of elasto‐inertial focusing in the oscillatory flows is revealed, and early detection of drug‐treated platelet aggregates and rapid cell ...
Yong Liu +3 more
wiley +1 more source
Clinical Guidelines for the Management of Adrenal Incidentaloma
Endocrinology and Metabolism, 2017 An adrenal incidentaloma is an adrenal mass found in an imaging study performed for other reasons unrelated to adrenal disease and often accompanied by obesity, diabetes, or hypertension.
Jung-Min Lee +13 more
semanticscholar +1 more source
Bioprinted Organoids: An Innovative Engine in Biomedicine
Advanced Science, EarlyView.Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li +11 more
wiley +1 more source
European Journal of Endocrinology, 2016 OBJECTIVE To comprehensively characterize androgens and androgen precursors in classic 21-hydroxylase deficiency (21OHD) and to gain insights into the mechanisms of their formation.
Adina F. Turcu +8 more
semanticscholar +1 more source