Results 191 to 200 of about 533,017 (267)

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

[Difficulty with differential diagnosis on adrenal lesions in congenital adrenal cortex dysfunction: a series of clinical cases]. [PDF]

Probl Endokrinol (Mosk)
Chevais A, Tarbaeva NV, Golubkina YY, Gadzhimuradova MM, Ivashchenko KV, Ladygina DO, Vorontsova MV, Bezlepkina OB, Melnichenko GA, Mokrysheva NG.   +9 more
europepmc   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Characterizing bone metastases and skeletal‐related events in patients with well‐differentiated neuroendocrine neoplasms utilizing 68Gallium‐DOTATATE positron emission tomography

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Tumors of neuroendocrine origin are a heterogenous group of related neoplasms which can arise from anywhere in the body. Neuroendocrine neoplasms (NENs) are categorized by site of origin, differentiation status and grade (Ki‐67 expression and/or mitotic rate), with significant prognostic variability accordingly. Historically, the prevalence of
Tucker W. Coston, Himil J. Mahadevia, Marie M. Plante, Alex Hochwald, Joseph M. Accurso, Akash Sharma, Geoffrey B. Johnson, Jonathan B. Ashman, A. Tuba Kendi, Mohamad Bassam Sonbol, Patrick W. McGarrah, Timothy J. Hobday, Thorvardur R. Halfdanarson, Jason S. Starr   +13 more
wiley   +1 more source

The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection. [PDF]

Front Endocrinol (Lausanne), 2020
Mao Y, Xu B, Guan W, Xu D, Li F, Ren R, Zhu X, Gao Y, Jiang L.   +8 more
europepmc   +1 more source

Evaluation of thyroglobulin autoantibodies in dogs at the time of diagnosis of hypoadrenocorticism and during treatment

Veterinary Record, Volume 199, Issue 8, Page e350-e358, 17/24 October 2026.
Abstract Background Autoimmune thyroiditis (AIT) may occur more frequently in dogs with hypoadrenocorticism (HA) than previously recognised. The objective of this study was to determine the presence of thyroglobulin autoantibodies (TgAAs) in dogs with HA.
Christin Emming, Sina Strey, Ina Leiter, Reinhard Mischke, Holger Volk, Marion Schmicke, Johanna Rieder   +6 more
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex.

Endocrinology
Abou Nader N, Jakuc N, Meinsohn MC, Charrier L, Banville L, Brind'Amour J, Paquet M, St-Jean G, Boerboom D, Mao J, Pépin D, Breault DT, Zamberlam G, Boyer A.   +13 more
europepmc   +1 more source

Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells. [PDF]

Sci Rep
Nasri A, Sands J, Unniappan S.
europepmc   +1 more source

c-KIT oncogene expression in PRKAR1A-mutant adrenal cortex. [PDF]

Endocr Relat Cancer, 2020
Nadella K, Faucz FR, Stratakis CA.
europepmc   +1 more source