Results 11 to 20 of about 650,508 (231)
We studied the endocrine mechanisms of urgent and long-term adaptation of children to increased physical stresses and, in particular, the role of hormones of the adrenal cortex in the regulation of the muscular activity of male athletes aged 11–15 years ...
M.V. Shaykhelislamova +4 more
doaj +1 more source
Single-cell and spatial transcriptomics analysis of human adrenal aging
Objective: The human adrenal cortex comprises three functionally and structurally distinct layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex undergoes functional and structural alteration or “adrenal aging ...
Norifusa Iwahashi +18 more
doaj +2 more sources
CLINICAL CASE OF 19-YEARS-OLD PATIENT WITH CONGENITAL ADRENAL CORTEX DYSFUNCTION
Congenital adrenal hyperplasia is caused by partial or complete block of enzymatic systems involved in the synthesis of steroid hormones of the adrenal cortex and leading to reduced production of glucocorticoids.
S I Ascolskaya +4 more
doaj +2 more sources
An integrated single-cell analysis of human adrenal cortex development
The adrenal glands synthesize and release essential steroid hormones such as cortisol and aldosterone, but many aspects of human adrenal gland development are not well understood.
Ignacio del Valle +16 more
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Adrenal cortex development and related disorders leading to adrenal insufficiency. [PDF]
The adult human adrenal cortex produces steroid hormones that are crucial for life, supporting immune response, glucose homeostasis, salt balance and sexual maturation. It consists of three histologically distinct and functionally specialized zones.
Flück, Christa E. +3 more
core +3 more sources
The role of primary cilia and sonic hedgehog signalling in adrenal development function. [PDF]
PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core +3 more sources
Background Glycogen storage disease type I (GSDI) is an inborn error of carbohydrate metabolism caused by mutations of either the G6PC gene (GSDIa) or the SLC37A4 gene (GSDIb).
Alessandro Rossi +9 more
doaj +1 more source
Chronic adrenal insufficiency is caused by insufficient secretion of hormones by the adrenal cortex due to dysfunction of one or more links of the hypothalamic-pituitary-adrenal system.
V. G. Chobitko, A. P. Belova
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A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads
Human fetal adrenal glands produce substantial amounts of dehydroepiandrosterone (DHEA), which is one of the most important precursors of sex hormones. However, the underlying biological mechanism remains largely unknown. Herein, we sequenced human fetal
Yifu Wang +93 more
doaj +1 more source
Mean plasma cortisol 4 to 6 hours after 1 mg Synacthen Depot in normal subjects, simple goiter and hypothyroidism were not significantly different. On the contrary after stimulation cortisol levels in untreated hyperthyroidism were significantly below ...
A. Galvão-Teles
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