Results 91 to 100 of about 18,480 (223)

Adrenal and Liver Transformations of Mitotane.

open access: yes, 1985
Mitotane, 1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane (o,p'-DDD), a structural analog of the insecticide DDT has found use in the treatment of neoplasms derived from the adrenal cortex as well as in the treatment of Cushing's syndrome due to
Freeman, Corinne Johnson
core  

SILVER BINDING NUCLEOLAR ORGANIZER REGIONS IN ADRENOCORTICAL NEOPLASIA

open access: yes, 1992
The possible contribution of the silver colloid technique for staining nucleolar organizer regions in the distinction between benign and malignant adrenocortical neoplasms was investigated.
OZ, B   +3 more
core   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

open access: yesVIEW, Volume 7, Issue 3, June 2026.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai   +11 more
wiley   +1 more source

Somatostatin receptor expression in adrenocortical carcinomas

open access: yes, 2018
Background. Adrenocortical carcinoma (ACC) is a rare malignant tumor characterized by an annual incidence of 0.5—2 cases per million population. Surgery is the-first line treatment for ACC.
Galina A. Mel’nichenko   +4 more
core   +1 more source

Maternal Intake of Dipteryx alata Vog. Reduces Offspring's Brain Oxidative Stress and Anxiety: Insights From In Silico and In Vivo Studies

open access: yesJournal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT We undertook a computational investigation and evaluation of the impact of maternal supplementation with baru almonds (Dipteryx alata Vog.) on anxiety‐like behavior and oxidative stress in the brains of adolescent and adult rat offspring. Molecular docking studies were conducted and revealed that the phenolic compounds (PCs) from the baru ...
Diego Elias Pereira   +12 more
wiley   +1 more source

From chromaffin cells to Phaeochromocytoma: insight into the sympathoadrenal cell lineage

open access: yes, 2007
Chromaffin cells are a modified post-ganglionic sympathetic neuron, which synthesise and secrete catecholamines. The neoplastic transformation of chromaffin cells is demonstrated by the tumour phaeochromocytoma, a functional tumour that recapitulates the
Cleary, Susannah
core  

Enhancing Dopamine Accumulation in Secretory Vesicles of PC12 Cells: Mechanisms, Applications and Limitations

open access: yesJournal of Neurochemistry, Volume 170, Issue 6, June 2026.
Schematic representation of a large dense‐core vesicle in PC12 cells highlighting its main molecular organization. The diagram illustrates the presence of membrane transporters, proton pumps and intravesicular matrix proteins that establish the electrochemical gradients required for neurotransmitter uptake, vesicle acidification and efficient storage ...
Noemi Socas‐Pérez   +2 more
wiley   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence?

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira   +1 more
wiley   +1 more source

A Multi‐Institutional Retrospective Study of 21 Dogs Having Undergone Hypofractionated Radiotherapy for Adrenal Tumours (2017–2024)

open access: yesVeterinary and Comparative Oncology, Volume 24, Issue 2, Page 229-239, June 2026.
ABSTRACT Radiation therapy (RT) has emerged as a promising non‐surgical approach for treating canine adrenal tumours. This multi‐institutional, retrospective study describes clinical outcomes for 21 dogs having been prescribed a course of hypofractionated image‐guided intensity‐modulated RT (IMRT) entailing delivery of 25–35 Gy total in 5 fractions ...
Yen‐Hao Erik Lai   +4 more
wiley   +1 more source

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