Results 151 to 160 of about 79,565 (318)

The Influence of Childhood Trauma on the Real‐World Effectiveness of Ketamine in Adults With Treatment‐Resistant Depression

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Childhood trauma is a well‐established risk factor for major depressive disorder (MDD) and is often associated with attenuated response to conventional antidepressant therapies. Ketamine has emerged as an effective treatment for treatment‐resistant depression (TRD), but the impact of childhood trauma on its effectiveness remains ...
Danica E. Johnson, Nelson B. Rodrigues, Rodrigo B. Mansur, Roger S. McIntyre, Joshua D. Rosenblat   +4 more
wiley   +1 more source

Clinical and Biological Remission With Tezepelumab: The Real‐World Response in Severe Uncontrolled Asthma

Allergy, EarlyView.
This study analyzed the clinical and biomarker data from 175 adults with severe asthma treated with the anti‐TSLP monoclonal antibody tezepelumab. Following tezepelumab initiation, the exacerbation rate decreased, with 59% of patients remaining exacerbation‐free at 1 year. Asthma symptom control as measured by ACQ‐6 significantly improved after 4 weeks
Jessica Gates, Faizan Haris, Francesca Cefaloni, Paniz Khooshemehri, Linda Green, Mariana Fernandes, Louise Thomson, Cris Roxas, Jodie Lam, Grainne d'Ancona, Alexandra M. Nanzer, Jaideep Dhariwal, David J. Jackson   +12 more
wiley   +1 more source

Acute Adrenal Insufficiency due to Isolated Corticotrophin Deficiency [PDF]

, 1979
R. J. M. Corrall, Gordon W. Stewart, J. G. Ratcliffe   +2 more
openalex   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

MACROGENITOSOMIA PRECOX ASSOCIATED WITH HYPERPLASIA OF THE ANDROGENIC TISSUE OF THE ADRENAL AND DEATH FROM CORTICOADRENAL INSUFFICIENCY CASE REPORT¹

, 1940
Lawson Wilkins, Walter Fleischmann, John Eager Howard   +2 more
openalex   +1 more source

Adrenal insufficiency in critically ill septic patients at Dr George Mukhari Hospital [PDF]

, 2006
Rationale: Adrenal insufficiency occurs with varying frequency in critically ill patients. It is usually associated with a high mortality and poor clinical outcome. Objective: To determine the incidence of adrenal failure in patients with severe sepsis
Mothabeng, TG, Mpe, MJ, Muleba, NC, Selepe, EM   +3 more
core   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

A Novel Use of Pseudospectra in Mathematical Biology: Understanding HPA Axis Sensitivity [PDF]

arXiv
The Hypothalamic-Pituitary-Adrenal (HPA) axis is a major neuroendocrine system, and its dysregulation is implicated in various diseases. This system also presents interesting mathematical challenges for modeling. We consider a nonlinear delay differential equation model and calculate pseudospectra of three different linearizations: a time-dependent ...
arxiv  

Endocrine Abnormalities and Growth Pattern in Single Large‐Scale Mitochondrial DNA Deletion Syndromes

Acta Paediatrica, EarlyView.
ABSTRACT Aim To assess the prevalence of endocrine disorders and investigate growth patterns in single large‐scale mitochondrial DNA deletion syndromes (SLSMDs). Methods A retrospective study of all children with SLSMD who attended Sheba Medical Center, Israel, from February 2017 to September 2024.
Ayman Daka, Einat Lahav, Omer Bar Yosef, Yoav Bolkier, Yael Levy‐Shraga, Yair Anikster, Elad Jacoby, Noah Gruber   +7 more
wiley   +1 more source

A CRH Theory of Autism Spectrum Disorder [PDF]

arXiv
This paper presents a complete theory of autism spectrum disorder (ASD), explaining its etiology, symptoms, and pathology. The core cause of ASD is excessive stress-induced postnatal release of corticotropin-releasing hormone (CRH). CRH competes with urocortins for binding to the CRH2 receptor, impairing their essential function in the utilization of ...
arxiv