Results 81 to 90 of about 221,430 (290)

A Case of primary adrenal lymphoma presenting with adrenal insufficiency

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2018
Non-Hodgkin lymphoma (NHL) with secondary involvement of the adrenal gland is not uncommon, however primary adrenal lymphoma leading to adrenal insufficiency is a rare occurrence.
G.P. Samarasinghe, C.N. Antonypillai, U.P. Kalubowila, R.M.P. Ratnayake, E.M.S.B. Ekanayake, B.M.I.K. Thilakarathne   +5 more
doaj   +1 more source

Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure [PDF]

, 2005
Disruption of the P450 side-chain cleavage cytochrome (P450scc) enzyme due to deleterious mutations of the CYP11A1 gene is thought to be incompatible with fetal survival because of impaired progesterone production by the fetoplacental unit.
Werner, R, Hiort, O, Achermann, JC, Riepe, FG, Partsch, CJ, Holterhus, PM, Marschke, C, Hoppe, U, Struve, D   +8 more
core  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Pediatric Adrenal Insufficiency: Challenges and Solutions

Therapeutics and Clinical Risk Management, 2022
Daniela Nisticò,1 Benedetta Bossini,1 Simone Benvenuto,1 Maria Chiara Pellegrin,1 Gianluca Tornese2 1University of Trieste, Trieste, Italy; 2Department of Pediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste ...
Nisticò D, Bossini B, Benvenuto S, Pellegrin MC, Tornese G   +4 more
doaj  

Evolving adrenal insufficiency

Indian Journal of Endocrinology and Metabolism, 2012
Tuberculosis is the most common cause of Addison's disease in India. The exact status of adrenal reserve in tuberculosis is still an enigma and recovery of adrenal function is unpredictable.We report a case with a pre-Addisonian state and unchanged adrenal size after 1 year treatment.A 31-year patient with adrenal tuberculosis was diagnosed and treated
Ajitesh Roy, Rana Bhattacharjee, Soumik Goswami, Anubhav Thukral, S Chitra, Partha Pratim Chakraborty, Dayanidhi Meher, Sujoy Ghosh, Satinath Mukhopadhyay, Subhankar Chowdhury   +9 more
openaire   +3 more sources

Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc [PDF]

, 2008
Context: Mitochondrial cytochrome P450scc converts cholesterol to pregnenolone in all steroidogenic tissues. Although progesterone production from the fetally-derived placenta is necessary to maintain pregnancy to term, four patients with mutations in ...
Huang, NW, Achermann, JC, Lin, L, Kim, CJ, Miller, WL, Quigley, CA, AvRuskin, TW   +6 more
core  

Central Adrenal Insufficiency and Diabetes Insipidus Misdiagnosed as Severe Depression

, 2010
A 68 year-old Japanese man, who had been suffering from immobilization and disuse syndrome, was admitted to our hospital for evaluation of polyuria with polyposia, hyponatremia and low blood pressure.
Mariko Higa, Gen Yoshino, Aya Yoshihara, Naoki Hiroi, Mariko Sue   +4 more
core   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Reversible dilated cardiomyopathy as a complication of adrenal cortex insufficiency: a case report

Journal of Medical Case Reports, 2018
Background Cardiovascular manifestations associated with Addison’s disease are previously documented. We described a case of an 11-year-old girl who developed dilated cardiomyopathy as a complication to Addison’s disease.
Mohammad Alkhateeb, Mohammad Alsakkal, Mohammad Nour Alfauri, Diana Alasmar   +3 more
doaj   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source