Results 81 to 90 of about 82,606 (343)

Isolated Corticospinal Tract Lesions as an Early Manifestation of Adrenoleukodystrophy in Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Purpose X‐linked adrenoleukodystrophy (ALD) encompasses a wide range of neurological manifestations, classically described as distinct phenotypes including childhood cerebral adrenoleukodystrophy and adult‐onset adrenomyeloneuropathy (AMN).
Elle Winter, Amanda Nagy, Yedda Li, Otto Rapalino, Catherine L. Becker, Joseph Locascio, Camilo Jaimes, Florian Eichler   +7 more
wiley   +1 more source

Serum macrophage migration inhibitory factor reflects adrenal function in the hypothalamo-pituitary-adrenal axis of septic patients: an observational study [PDF]

, 2009
Background The hypothalamo-pituitary-adrenal (HPA) axis modulates the inflammatory response during sepsis. Macrophage migration inhibitory factor (MIF), which counteracts the anti-inflammatory activity of glucocorticoid (GC), is one of the mediators of ...
Takashi Miyauchi, Ryoske Tsuruta, Motoki Fujita, Tadashi Kaneko, Shunji Kasaoka, Tsuyoshi Maekawa, E Rivers, G Van den Berghe, JL Vincent, F Lauzier, C Vinsonneau, JA Russell, DN Cruz, D Annane, H Gonzalez, D Keh, M Confalonieri, R Lefering, F Zeni, B Bloom, T Calandra, J Nishihira, J Bernhagen, T Calandra, The ACCP/SCCM Consensus Conference Committee, D Annane, D Annane, PE Marik, A Beishuizen, FA Bozza, T Sprong, M Emonts, V Maxime, JT Ho, MF De Jong, MF De Jong, IE Widmer, H Makita, S Gando, M Vogeser   +39 more
core   +2 more sources

Political Social Identity Threat Predicts Increases in Affective Polarisation Over Time, but Not Changes in Well‐Being

European Journal of Social Psychology, EarlyView.
ABSTRACT Affective polarisation, a growing hostility toward political outgroups, is a phenomenon rooted in social identity. Social identity threat—the expectation of experiencing some form of denigration based on a self‐relevant group identity—is thought to be a major driver of affective polarisation.
Brandon McMurtrie, Matt Williams, Michael Philipp, Anja Roemer, Ross Hebden   +4 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Guidelines regarding management of adrenal insufficiency in the Holy month of Ramadan

Indian Journal of Endocrinology and Metabolism, 2012
Adrenal insufficiency is a life-threatening event, so it is recommended for patients with known adrenal insufficiency to be properly educated regarding sick-day management.
Sheelu S Siddiqi, S K Singh, Shakeel Ahamad Khan, Osama Ishtiaq, Md. Faruque Pathan, Syed Abbas Raza, A K Azad Khan, Abdul Hamid Zargar, Ganapathy Bantwal   +8 more
doaj   +1 more source

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

Health Care Science, EarlyView.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang, Zebin Zhu, Hao Zheng, Can Qi, Xiaodong Yuan, Xuefeng Li, Zhijun Xu, Jiwei Qin, Wei Wu, Jizhou Wang, Ruipeng Song, Zhiyong Guo, Lianxin Liu, Shu‐Geng Zhang, Björn Nashan   +14 more
wiley   +1 more source

The hypothalamic-pituitary-adrenal axis in critical illness [PDF]

, 1993
Plasma ACTH and cortisol concentrations are frequently elevated in patients in intensive care units (ICU). To examine the functional integrity of the hypothalamic-pituitary-adrenal axis during critical illness, we evaluated prospectively 53 ICU patients ...
Allolio, B., Reincke, Martin, Winkelmann, W., Würth, G.   +3 more
core  

Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. [PDF]

, 2017
ObjectiveTo analyze reasons for low enrollment in a randomized controlled trial (RCT) of the effect of hydrocortisone for cardiovascular insufficiency on survival without neurodevelopmental impairment (NDI) in term/late preterm newborns.Study designThe ...
A Das, A F Duncan, B B Poindexter, B Carper, B J Stoll, C B Lacy, C Gauldin, C M Cotten, E F Bell, E Fernandez, G M Sokol, K A Kennedy, K L Watterberg, K P Van Meurs, M C Walsh, M H Wyckoff, M V Fraga, null null, P J Sanchez, R D Higgins, S Chawla, S Lakshminrusimha, S S Beauman, U Devaskar, W A Carlo, W E Truog, W F Buss   +26 more
core   +1 more source

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, EarlyView.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source

Hypothyroidism and nephrotic syndrome: why, when and how to treat [PDF]

, 2017
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS).
Barbano, Biagio, Cianci, Rosario, Di Mario, Francesca, Gigante, Antonietta, Isidori, Andrea, Pofi, Riccardo, Rivoli, Laura, Rosato, Edoardo   +7 more
core   +1 more source