Results 211 to 220 of about 79,434 (274)

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji   +10 more
wiley   +1 more source

Locus coeruleus alterations in dementia with Lewy bodies: A systematic review

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is a small nucleus located deep within the brainstem, serving as the brain's main source of noradrenergic neurons. Through its extensive projections, it plays a critical role in regulating cognitive processes and arousal.
Anaëlle Bain   +5 more
wiley   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

open access: yesJournal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki   +8 more
wiley   +1 more source

Choosing the right antihypertensive drug to avoid intradialytic hypotension. [PDF]

open access: yesClin Kidney J
Zoccali C   +5 more
europepmc   +1 more source

Haemodynamic Changes After Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine Versus Placebo During Induction of General Anaesthesia: A Randomised Trial

open access: yesActa Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Ephedrine, phenylephrine, and norepinephrine are commonly used to manage hypotension during the induction of anaesthesia. The objective of this study was to evaluate whether prophylactic administration of assumed equipotent doses of these vasopressors could maintain systolic arterial blood pressure (SAP) and heart rate (HR) within ...
Gunnar Helge Sjøen   +4 more
wiley   +1 more source

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