Results 41 to 50 of about 104,693 (298)

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]

, 2016
Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael, Di Nardo, Anna, Docherty, James R, Holmes, Anna, Lorton, Dianne, Schäfer, Gregor, Steinhoff, Martin   +6 more
core   +2 more sources

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, EarlyView., 2023
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes [PDF]

, 2017
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR).
Blaauw, Bert, Borgia, Doriana, Gomes Pereira, Marcelo, Lieberman, Andrew P., Maino, Eleonora, Malena, Adriana, Marchioretti, Caterina, Milioto, Carmelo, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Plebani, Mario, Polanco, Maria J., Sambataro, Fabio, Sambataro, Fabio, Sorar, Gianni, Soraru', Gianni, Venturini, Roberta, Vergani, Lodovica   +18 more
core   +3 more sources

Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.

Journal of Biological Chemistry, 2001
Although agonist binding in adrenergic receptors is fairly well understood and involves residues located in transmembrane domains 3 through 6, there are few residues reported that are involved in antagonist binding.
D. Waugh, R. Gaivin, M. Zuscik, P. Gonzalez-Cabrera, S. Ross, J. Yun, D. Perez   +6 more
semanticscholar   +1 more source

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas) [PDF]

, 2011
This is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Eccles, PD, Giltrow, E, Hutchinson, TH, Rand-Weaver, M, Sumpter, JP   +4 more
core   +1 more source

The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications

Angewandte Chemie, EarlyView.
The dual redox nature of polyphenols enables antioxidant activity and controlled reactive oxygen species (ROS) generation. This review details the biomedical applications of polyphenols in materials such as nanoparticles, coatings, and hydrogels for antimicrobial, tissue regeneration, and cancer therapies.
Jose Bolaños‐Cardet, Belén Pepió‐Tárrega, Javier Saiz‐Poseu, Alba López‐Moral, Faiz Ullah, Victor J. Yuste, Daniel Ruiz‐Molina, Salvio Suárez‐García   +7 more
wiley   +2 more sources

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source