Results 61 to 70 of about 31,393 (254)

Comparison of efficacy between intravenous clonidine and dexmedetomidine as pre-medication in attenuating hemodynamic stress responses during laparoscopic cholecystectomy

Asian Journal of Medical Sciences, 2023
Background: Laparoscopic cholecystectomy is a commonly performed surgery and stable intraoperative hemodynamic status is desirable during pneumoperitonium.
Diptimay Majumder , Susanta Kumar Halder, Swarup Datta , Sruthi Naresh , Soma Chakraborty , Subrata Pahari   +5 more
doaj   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source

The efficacy and safety of epidural dexmedetomidine and clonidine with bupivacaine in patients undergoing lower limb orthopedic surgeries

Journal of Anaesthesiology Clinical Pharmacology, 2016
Background and Aims: Alpha (α-2) adrenergic agonists have both analgesic and sedative properties when used as an adjuvant in regional anesthesia. A prospective randomized double-blind study was carried out to evaluate the efficacy of epidural route and ...
Safiya I Shaikh, Sarala B Mahesh
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Alpha(2)-adrenergic agonists for the management of opioid withdrawal

, 2009
Published Online: 15 APR 2009BACKGROUND: Withdrawal is a necessary step prior to drug-free treatment or as the end point of long-term substitution treatment.
Gowing, L., Farrell, Michael, White, J., Ali, R., Robert Ali, Ali, Robert, Jason M White, Michael Farrell, Farrell, M., Linda Gowing, Gowing, Linda, White, Jason M.   +11 more
core   +1 more source

The medical management of glaucoma

South African Family Practice, 2017
Glaucoma is one of the leading causes of blindness worldwide. The main characteristic features include optic disc cupping, visual field loss, and in most instances a raised intraocular pressure.
André Marais, Elzbieta Osuch
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Cardiac adrenergic control and atrial fibrillation [PDF]

, 2010
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic balance, has a profound influence on the occurrence of AF ...
Workman, A.J.
core   +1 more source

Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation

Brazilian Journal of Medical and Biological Research, 2001
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed.
Puscas I., Coltau M., Gilau L., Pasca R., Domuta G., Baican M., Hecht A.   +6 more
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