Results 51 to 60 of about 46,059 (254)

Exploring barriers to utilizing local agricultural products in the catering industry

Agribusiness, EarlyView.
Abstract Both the proportion and expenditure of dining out and takeaway in Taiwan have been increasing year by year. This study investigates the factors influencing the catering service providers (CSPs) procurement of domestically produced or imported food materials.
Wan‐Yu Liu, Hsing‐Wei Lin, Chun‐Cheng Lin   +2 more
wiley   +1 more source

Trends in first‐line monotherapy and combination therapy for hypertension in UK primary care

British Journal of Clinical Pharmacology, EarlyView.
Aims Debate remains about the optimal initial treatment strategy for hypertension. Most guidelines recommend first‐line combination therapy for most patients. However, the UK's National Institute for Health and Care Excellence recommends first‐line monotherapy for all patients.
Kyle Johnson, Sarah Beradid, James M. Brophy, Robert W. Platt, Christel Renoux   +4 more
wiley   +1 more source

Cost-effectiveness of glaucoma management with monotherapy medications in Egypt

Journal of Advanced Pharmaceutical Technology & Research, 2017
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic ...
Amal Abd-Elaal El-Khamery, Amir Ibrahim Mohamed, Hassan Eisa Hassan Swify, Alaa Ibrahim Mohamed   +3 more
doaj   +1 more source

α_1L-adrenoceptors mediate contraction of human erectile tissue [PDF]

, 2018
α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated
Campbell, Alistair, Chapple, Christopher R., Chess-Williams, Russ, Davis, Beverley J., Naylor, Alisdair L., Sellers, Donna J., Sillar, David   +6 more
core   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, EarlyView.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review. [PDF]

Am J Addict
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Owusu-Antwi P, Atodaria P, Appiah-Kubi E, Shah Z, Garcia EM.   +4 more
europepmc   +2 more sources

Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry.
Angela Palma Amorin, Sandra Layse Ferreira Sarrazin, Leomara Andrade da Silva, Thaiana Neves Coelho, Adriele Pantoja Cunha, Vitória Albuquerque de Lima, Domingas Machado da Silva, Pablo Luis Baia Figueiredo, Ricardo Bezerra de Oliveira   +8 more
wiley   +1 more source

The efficacy and safety of epidural dexmedetomidine and clonidine with bupivacaine in patients undergoing lower limb orthopedic surgeries

Journal of Anaesthesiology Clinical Pharmacology, 2016
Background and Aims: Alpha (α-2) adrenergic agonists have both analgesic and sedative properties when used as an adjuvant in regional anesthesia. A prospective randomized double-blind study was carried out to evaluate the efficacy of epidural route and ...
Safiya I Shaikh, Sarala B Mahesh
doaj   +1 more source

Adjuvant dexmedetomidine in treatment of alcohol withdrawal delirium: Case series

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Alcohol withdrawal delirium is a medical emergency with mortality rates of 20–50% without treatment. Benzodiazepines (BZDs) (gamma-aminobutyric acid receptor agonists) are the mainstay of treatment.
Amit Chail, Madhubrata Ray, Ranveer Singh, Mayank Dhiman   +3 more
doaj   +1 more source

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources