Results 71 to 80 of about 79,434 (274)

Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial [PDF]

, 2022
Bjørn Erik Neerland, Rolf Busund, Rune Haaverstad, Jorunn L. Helbostad, Svein Aslak Landsverk, Ieva Martinaityte, Hilde M. Norum, Johan Ræder, Geir Selbæk, Melanie Rae Simpson, Elisabeth Skaar, Nils Kristian Skjærvold, Eva Skovlund, Arjen J. C. Slooter, Øyvind S. Svendsen, Theis Tønnessen, Alexander Wahba, Henrik Zetterberg, Torgeir Bruun Wyller   +18 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

High platelet adrenergic activity and concomitant activation of the pituitary/medullar axis as alarming laboratory parameters in ACS survivors—the STRESS-AMI study

Frontiers in Cardiovascular Medicine
IntroductionKinetics of stress-related biological parameters were determined in acute coronary syndrome (ACS) patients undergoing complex cardiovascular rehabilitation.MethodsWe determined platelet functionality in the absence/presence of a selective ...
Zalán Gulyás, Zsófia Horváth, László Hajtman, Andrea Kovács, László Kohut, István Kósa, Emese Tóth-Zsámboki, Róbert Gábor Kiss   +7 more
doaj   +1 more source

Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists [PDF]

, 2020
Mónica Madrigal‐Valverde, Rodrigo Freitas Bittencourt, Antonio DL Ribeiro Filho, Vivian Fernanda Barbosa, Catharina de Albuquerque Vieira, Elton Amorim Romão, Isabella B Carneiro, M.C. Azevedo, Gediendson Ribeiro de Araújo   +8 more
openalex   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Double-J Stent: Symptoms, Complications and Pharmacological Management: A Comprehensive Review [PDF]

Translational Research in Urology
Introduction: Double-J (DJ) ureteral stents are essential to modern urological therapy because they allow internal urine drainage in a variety of clinical contexts, such as obstructive uropathy, postoperative support, and short-term ureteral blockage ...
Diksha jindal, Mehwish Gull, Bikram Swargiary   +2 more
doaj   +1 more source

The alpha 1-adrenergic agonist methoxamine and the "loop" diuretic frusemide reduce nasal potential difference [PDF]

, 1991
AM Wood, Anh Tuan Dinh‐Xuan, George Cremona, A Lockhart, TW Higenbottam   +4 more
openalex   +1 more source