Results 81 to 90 of about 101,334 (285)

Renoprotective and haemodynamic effects of adiponectin and peroxisome proliferator-activated receptor agonist, pioglitazone, in renal vasculature of diabetic Spontaneously hypertensive rats.

PLoS ONE, 2020
Pioglitazone, a therapeutic drug for diabetes, possesses full PPAR-γ agonist activity and increase circulating adiponectin plasma concentration. Plasma adiponectin concentration decreases in hypertensive patients with renal dysfunctions.
Sheryar Afzal, Munavvar Abdul Sattar, Edward James Johns, Olorunfemi A Eseyin   +3 more
doaj   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Avaliação da dexmedetomidina e do tramadol, associados ao midazolam, em gatas anestesiadas com isoflurano e submetidas à ovário-histerectomia

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Objetivou-se comparar as alterações cardiorrespiratórias e a analgesia pós-operatória promovidas pela dexmedetomidina e pelo tramadol, quando associados ao midazolam, em felinas.
V.C.C. Lemos, J.Q. Sande, V.F. Barbosa, J.M. Costa Neto, E.F. Martins Filho, C.H.D. Iwassa   +5 more
doaj   +1 more source

β-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-greek small letter alpha expression in adipocytes [PDF]

, 2007
Recently, the insulin-sensitizing adipokine adiponectin and the insulin resistance-inducing adipokine tumor necrosis factor-greek small letter alpha (TNF-greek small letter alpha) were reported to inhibit each other\u27s production in adipocytes.
Fu Ling, Isobe Kazumasa, Kawakami Yasushi, Suzukawa Kazumi, Takekoshi Kazuhiro, Zeng Qin, 傅 玲, 川上 康, 磯部 和正, 竹越 一博, 鈴川 和己   +10 more
core   +1 more source

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso, Davide Stolfo, Markus S. Anker, Antoni Bayes‐Genis, Ovidiu Chioncel, Stephane Heymans, Pardeep S. Jhund, Basil S. Lewis, Gary D. Lopaschuk, Lars H. Lund, Arantxa Gonzalez, Matteo Pagnesi, Gabriele Giacomo Schiattarella, Carlo Gabriele Tocchetti, Peter van der Meer, Sophie Van Linthout, Sven Wassmann, B. Daan Westenbrink, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +20 more
wiley   +1 more source

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

Effectiveness and Safety of Dupilumab Monotherapy in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyps

The Laryngoscope, EarlyView.
In this phase 4, open‐label, single‐arm, multicenter study, dupilumab monotherapy was associated with reductions from baseline to week 24 (primary endpoint) in the bilateral endoscopic Nasal Polyp Score (NPS) in 25 Japanese adults with inadequately controlled chronic rhinosinusitis with nasal polyps on standard care therapies.
Shigeharu Fujieda, Tetsuji Takabayashi, Nobuo Ohta, Mamoru Yoshikawa, Yuki Kibe, Masato Ishida, Katsuhisa Suzuki, Yoshinori Takahashi, Nikhil Amin, Lakiea Wright, Lacey Robinson, Kenji Yahata   +11 more
wiley   +1 more source

Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment [PDF]

РМЖ "Клиническая офтальмология", 2019
The article reviews historical aspects of direct and indirect (by reducing intraocular pressure (IOP)) neuroprotective effect of brimonidine in terms of modern views on glaucoma monitoring and treatment.
V.P. Erichev, S.Yu. Petrov, A.V. Volzhanin, D.M. Safonova, T.V. Yaremenko, S.A. Kazaryan   +5 more
doaj  

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source